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https://doi.org/10.14300/mnnc.2022.17028

Pseudoarthrosis: search for treatment methods of delayed consolidation and non-union

[Reviews]
Valery G. Samodai; Andrey Olegovich Starikov; Pavel Ivanovich Kalashnikov; Pavel Anatolyevich Mandroshchenko;

There are many technologies and ways to influence the area compromised by trauma in order to avoid complications, which today take the form of traumatic epidemics. On average, 40–50 % of fracture healing cases occur with delayed consolidation and the formation of pseudoarthrosis. The use of modern orthobiological methods of normalization of regenerative osteogenesis allows us to achieve good results. However, a large selection of modern technologies for influencing the links of osteogenesis does not mean greater accessibility. Many bioengineering methods have a high cost of technological processes, require special conditions for application, which imposes restrictions on the use of the latest highly effective tools. Currently, the «gold standard», an affordable way to stimulate the osteogenetic process is bone grafting. A compromise between bioengineering technologies and bone grafting is the use of lyophilized platelet growth factors derived from allogeneic blood. This is an inexpensive, promising technique that, in combination with bone grafting, gives good results. This article presents information about the most used materials and methods of stimulation of regenerative osteogenesis to date.

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Keywords: pseudoarthrosis, delayed consolidation, non-union, platelet-rich plasma, lyophilized growth factors, growth factors, PDGF, reparative osteogenesis