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EBSCO

https://doi.org/10.14300/mnnc.2022.17020

Evaluation of cytotoxicity of collagen -containing gels on experimental samples of biomaterials

[Abstracts]
Alexander Dolgalev; Evgeny Mikhailovich Boyko; Evgeny Mikhailovich Boyko; Dmitry Bobryshev; Nikolay Didenko; Yulia Aleksandrovna Glumskova;

Cytotoxicity, proliferative activity and the dynamics of the number of cell cultures were evaluated using experimental gel samples from the pericardium of cattle and the submucosa of the small intestine of pigs. The samples do not have cytotoxicity, do not interfere with mitotic activity and the increase in the number of human bone marrow mesenchymal stromal cells. The obtained data provide a basis for conducting in vivo studies of the products effectiveness and safety on laboratory animals.

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References:
1. Kirkness M. W., Lehmann K., Forde N. R. Mechanics and structural stability of the collagen triple helix. Curr. Opin. Chem. Biol. 2019;53:98-105. https://doi.org/10.1016/j.cbpa.2019.08.001
2. Tang V. W. Collagen, stiffness, and adhesion: the evolutionary basis of vertebrate mechanobiology. Mol. Biol. Cell. 2020;31(17):1823-1834. https://doi.org/10.1091/mbc.E19-12-0709
3. Avendano A., Chang J. J., Cortes-Medina M. G., Seibel A. J., Admasu B. R. [et al.]. Integrated Biophysical Characterization of Fibrillar Collagen-Based Hydrogels. ACS Biomater. Sci. Eng. 2020;6(3):1408-1417. https://doi.org/10.1021/acsbiomaterials.9b01873
4. Dolgalev A. A., Venediktov A. A., Bobryshev D. V., Kruchinina A. D., Chagarov A. A. [et al.]. Study of biocompatibility of the material based on small intestinal submucosa in tests in vitro and in vivo. Geni i Kletki. – Genes and Cells. 2019;14(2):47-51. (In Russ). https://doi.org/10.23868/201906018

Keywords: collagen gel, extracellular matrix, implantation