of the North Caucasus
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The antibacterial activity spectrum of defensin HNP-1 included in to the chitosan nanoparticles
[Abstracts]
Vladimir Baturin; Albert Bolatchiev; Andrey Mikhailovich Zhirov;
The antimicrobial activity of the antimicrobial peptide, defensin HNP-1 included in to the chitosan nanoparticles, against gram-positive and gram-negative bacteria was studied. In vitro, antimicrobial peptides included in chitosan nanoparticles can reduce their antimicrobial activity, that requires the study of the compounds being developed on models of infections in experimental animals.
References:
1. Roca I., Akova M., Baquero F., Carlet J., Cavaleri M. [et al.]. The global threat of antimicrobial resistance: Science for intervention. New Microbes New Infect. 2015;6:22-29. https://doi.org/10.1016/j.nmni.2015.02.007
2. Pachón-Ibáñez M. E., Smani Y., Pachón J., Sánchez-Céspedes J. Perspectives for clinical use of engineered human host defense antimicrobial peptides. FEMS Microbiol. Rev. 2017;41(3):323-342. https://doi.org/10.1093/femsre/fux012
3. Calvo P., Remuñan-López C., Vila-Jato J.-L., Alonso M. J. Chitosan and chitosan/ethylene oxide-propylene oxide block copolymer nanoparticles as novel carriers for proteins and vaccines. Pharmaceutiс. Res. 1997;14(10):1431-1436. https://doi.org/10.1023/A:1012128907225
4. Bolatchiev A., Baturin V., Bazikov I., Maltsev A., Kunitsina E. Effect of antimicrobial peptides HNP-1 and hBD-1 on Staphylococcus aureus strains in vitro and in vivo. Fundamental Clin. Pharmacol. 2020;34(1):102-108. https://doi.org/10.1111/fcp.12499
5. Presicce P., Giannelli S., Taddeo A., Villa M. L., Della Bella S. Human defensins activate monocyte-derived dendritic cells, promote the production of proinflammatory cytokines, and up-regulate the surface expression of CD91. J. Leuk. Biol. 2009;86(4):941-948. https://doi.org/10.1189/jlb.0708412
Keywords: antimicrobial peptides, defensins, antibiotic resistance, HNP-1, chitosan
Founders:
Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy