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[Abstracts]
Vladimir Baturin; Albert Bolatchiev; Andrey Mikhailovich Zhirov;
The antimicrobial activity of the antimicrobial peptide, defensin HNP-1 included in to the chitosan nanoparticles, against gram-positive and gram-negative bacteria was studied. In vitro, antimicrobial peptides included in chitosan nanoparticles can reduce their antimicrobial activity, that requires the study of the compounds being developed on models of infections in experimental animals.
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4. Bolatchiev A., Baturin V., Bazikov I., Maltsev A., Kunitsina E. Effect of antimicrobial peptides HNP-1 and hBD-1 on Staphylococcus aureus strains in vitro and in vivo. Fundamental Clin. Pharmacol. 2020;34(1):102-108. https://doi.org/10.1111/fcp.12499
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Keywords: antimicrobial peptides, defensins, antibiotic resistance, HNP-1, chitosan