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Polymorphic markers of innate immunity receptor genes in newborns with hypoxic-ischemic CNS damage

[Pediatrics]
Aminat Idrisova; Lyudmila Barycheva; Ekaterina Sergeevna Kuzmina; Kazbek Sultanovich Mezhidov; Oleg Agranovich; Marina Golubeva;

We examined 32 full–term newborns with grade 2 HIE and 13 with grade 3 HIE. Adverse neurological consequences were formed in 47.4 % of children. The probability of severe cerebral ischemia increased in residents of the homozygous genotype for the minor allele TLR6 T745T (OR=4.60, CI: 0.82–70.16), unfavorable HIE outcomes – in owners of the major allele TLR2 2258G (OR=6.50, CI: 0.746–56.64) and homozygous genotypes TLR2 G2258G (OR=7.60, CI: 0.82–70.16) and TLR6 T745T (OR=4.25; CI: 0.947–19.07). High levels of serum interleukins IL-1β, IL-6 in children with HIE are associated with genotypes G2258G and T745T.

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Keywords: hypoxic-ischemic encephalopathy, innate immunity receptors, gene polymorphism


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