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https://doi.org/10.14300/mnnc.2020.15106

Portal vein thrombosis in the practice of the internist

[Reviews]
Boleslav Levitan; Vsevolod Vladimirovich Skvortsov; Georgy Ilyich Malyakin;

Portal vein thrombosis (PVT) is a type of venous thrombosis that causes impairment or termination of blood flow inside the portal vein. PVT is caused by a combination of local and systemic risk factors. PVT in cirrhosis is accompanied by an increased risk of both hemorrhagic and thrombotic complications. PVT can be classified according to the time of development, localization, pathophysiology and complications. Ultrasound, CT and MRI play an important role in the evaluation of this condition. The range of treatment for PVT includes close monitoring without intervention, anticoagulation, thrombolysis, thrombectomy, angioplasty, and transjugular intrahepatic portosystemic shunt. According to the EASL clinical guidelines for vascular diseases of the liver, the use of direct-acting anticoagulants is recommended. Rivaroxaban, as well as other direct oral anticoagulants, are promising drugs for the treatment of PVT due to their advantages.

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References:
1. Del Carmen Manzano-Robleda M., Barranco-Fragoso B., Uribe M., Méndez-Sánchez N. Portal vein thrombosis: What is new? Ann. Hepatol. 2015;14(1):20-27. https://doi.org/10.1016/s1665-2681(19)30797-5
2. De Leve L. D., Valla D. C., Garcia-Tsao G. American Association for the Study Liver Diseases. Vascular disorders of the liver. Hepatology. 2009;49(5):1729-1764. https://doi.org/10.1002/hep.22772
3. Young K., Wong R. Evaluation and management of acute and chronic portal vein thrombosis in patients with cirrhosis. Clin. Liver Dis. (Hoboken). 2017;10(6):152-156. https://doi.org/10.1002/cld.679
4. Wu M., Schuster M., Tadros M. Update on Management of Portal Vein Thrombosis and the Role of Novel Anticoagulants. J. Clin. Transl. Hepatol. 2019;7(2):154-164. https://doi.org/10.14218/JCTH.2018.00057
5. Ögren M., Bergqvist D., Björck S., Acosta S., Eriksson H., Sternby N. H. Portal vein thrombosis: Prevalence, patient characteristics and lifetime risk: A population study based on 23 796 consecutive autopsies. World. J. Gastroenterol. 2006;12(13):2115. https://doi.org/10.3748/wjg.v12.i13.2115
6. Ageno W., Dentali F., Pomero F., Fenoglio L., Squizzato A. [et al.]. Incidence rates and case fatality rates of portal vein thrombosis and Budd-Chiari Syndrome. Thromb. Haemost. 2017;117(4):794-800. https://doi.org/10.1160/TH16-10-0781
7. Valla D., Condat B., Lebrec D. Spectrum of portal vein thrombosis in the West. J. Gastroenterol. Hepatol. 2002;17(s3):S224-S227. https://doi.org/10.1046/j.1440-1746.17.s3.4.x
8. Trebicka J., Strassburg C. Etiology and Complications of Portal Vein Thrombosis. Viszeralmedizin. 2014;30(6):7-7. https://doi.org/10.1159/000369987
9. Rajani R., Björnsson E., Bergquist A., Danielsson A., Gustavsson A. [et al.]. The epidemiology and clinical features of portal vein thrombosis: a multicentre study. Aliment. Pharmacol. Ther. 2010;32(9):1154-1162. https://doi.org/10.1111/j.1365-2036.2010.04454.x
10. Reena C., Satinderpal S. K., Amit D. K. Portal Vein Thrombosis: Imaging the Spectrum of Disease With an Emphasis on MRI Features. Am. J. Roentgenol. 2018;211(1):14-24. https://doi.org/10.2214/AJR.18.19548
11. Nadinskaia M. Yu., Kodzoeva Kh. B., Ulyanova K. A., Volkova A. S., Rogacheva S. I. [ et al.]. Risk factors associated with portal vein thrombosis in liver cirrhosis: A case-control study. Therapevtichesky archive. – Therapeutic archive. 2019;91(2):73-81. (In Russ.). https://doi.org/10.26442/00403660.2019.02.000153
12. Ponziani F. R., Zocco M. A., Campanale C., Rinninella E., Tortora A. [et al.]. Portal vein thrombosis: Insight into physiopathology, diagnosis, and treatment. World J. Gastroenterol. 2010;16(2):143-155. https://doi.org/10.3748/wjg.v16.i2.143
13. EASL Clinical Practice Guidelines: Vascular diseases of the liver. J. Hepatol. 2016;64(1):179-202. https://doi.org/10.1016/j.jhep.2015.07.040
14. Sarin S. K., Philips C. A., Kamath P. S., Choudhury A., Maruyama H. [et al.]. Toward a comprehensive new classification of portal vein thrombosis in patients with cirrhosis. Gastroenterology. 2016;151(4):574-577. https://doi.org/10. 1053/j.gastro.2016.08.033
15. Cagin Y. F., Atayan Y., Erdogan M. A., Dagtekin F., Colak C. Incidence and clinical presentation of portal vein thrombosis in cirrhotic patients. Hepatobiliary Pancreat. Dis. Int. 2016;15(5):499-503. https://doi.org/10.1016/S1499-3872(16)60092-9
16. Margini C., Berzigotti A. Portal vein thrombosis: The role of imaging in the clinical setting. Dig. Liver Dis. 2017;49(2):113-120. https://doi.org/10.1016/j.dld.2016.11.013
17. Wani Z. A., Bhat R. A., Bhadoria A. S., Maiwall R. Extrahepatic portal vein obstruction and portal vein thrombosis in special situations: Need for a new classification. Saudi. J. Gastroenterol. 2015;21(3):129-138. https://doi.org/10.4103/1319-3767.157550
18. Tripodi A., Primignani M., Braham S., Chantarangkul V., Clerici M. [et al.]. Coagulation parameters in patients with cirrhosis and portal vein thrombosis treated sequentially with low molecular weight heparin and vitamin K antagonists. Dig. Liver. Dis. 2016;48(10):1208-1213. https://doi.org/10.1016/j.dld.2016.06.027
19. Loffredo L., Pastori D., Farcomeni A., Violi F. Effects of Anticoagulants in Patients With Cirrhosis and Portal Vein Thrombosis: A Systematic Review and Meta-analysis. Gastroenterology. 2017;153(2):480-487. https://doi.org/10.1053/j.gastro.2017.04.042
20. Intagliata N. M., Caldwell S. H., Tripodi A. Diagnosis, Development, and Treatment of Portal Vein Thrombosis in Patients With and Without Cirrhosis. Gastroenterology. 2019;156(6):1582-1599. https://doi.org/10.1053/j.gastro.2019.01.265
21. Joppa S. A., Salciccioli J., Adamski J., Patel S., Wysokinski W. E. [et al.]. Practical Review of the Emerging Direct Anticoagulants, Laboratory Monitoring, and Reversal Agents. J. Clin. Med. 2018;7(2):29. https://doi.org/10.3390/jcm7020029
22. Warkentin T. E., Pai M., Linkins L. A. Direct oral anticoagulants for treatment of HIT: update of Hamilton experience and literature review. Blood. 2017;130(9):1104-1113. https://doi.org/10.1182/blood-2017-04-778993
23. Martinez M., Tandra A., Vuppalanchi R. Treatment of acute portal vein thrombosis by nontraditional anticoagulation. Hepatology. 2014;60(1):425-426. https://doi.org/10.1002/hep.26998
24. Lenz K., Dieplinger B., Buder R., Piringer P., Rauch M., Voglmayr M. Successful Treatment of Partial Portal Vein Thrombosis (PVT) with Low Dose Rivaroxaban. Zeitschrift. für Gastroenterologie. 2014;52(10):1175-1177. https://doi.org/10.1055/s-0034-1385171
25. Yang H., Kim S., Song M. Recurrent acute portal vein thrombosis in liver cirrhosis treated by rivaroxaban. Clin. Mol. Hepatol. 2016;22(4):499-502. https://doi.org/10.3350/cmh.2016.0016
26. Заклякова Л. В., Левитан Б. Н., Болгова М. Ю., Скворцов В. В., Закляков И. К. Клинический случай хронического тромбоза воротной вены. Терапевт. 2020;(2):27-41. [Zaklyakova L. V., Levitan B. N., Bolgova M. Yu., Skvortsov V. V., Zaklyakov I. K. Clinical case of chronic portal vein thrombosis. Terapevt. – Therapist. 2020;(2):27-41. (In Russ.)]. https://doi.org/10.33920/MED-12-2002-04
27. Klinger C., Riecken B., Schmidt A., De Gottardi A., Meier B. [et al.]. Transjugular local thrombolysis with/without TIPS in patients with acute non-cirrhotic, non-malignant portal vein thrombosis. Dig. Liver Dis. 2017;49(12):1345-1352. https://doi.org/10.1016/j.dld.2017.05.020
28. Kallini J. R., Gabr A., Kulik L., Ganger D., Lewandowski R. [et al.]. Noncirrhotic complete obliterative portal vein thrombosis: Novel management using trans-splenic transjugular intrahepatic portosystemic shunt with portal
vein recanalization. Hepatology. 2016;63(4):1387-1390. https://doi.org/10.1002/hep.28429
29. Jha R., Khera S., Kalaria A. Portal Vein Thrombosis: Imaging the Spectrum of Disease With an Emphasis on MRI Features. Am. J. Roentgenol. 2018;211(1):14-24. https://doi.org/10.2214/ajr.18.19548

Keywords: portal vein thrombosis, liver cirrhosis, direct oral anticoagulants