Medical news
of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137

Site search

Correspondence address
310 Mira Street, Stavropol, Russia, 355017

+7 865 2352511, +7 865 2353229.


Disorders of mineral metabolism as a predictor of sialolithiasis

Marina Kozlova; Anastasia Sergeevna Belyakova;

In 60 patients with calculous sialoadenitis of the submandibular salivary gland, the state of mineral metabolism was studied before and after the concrementectomy. An increase in the secretion of parathyroid hormone, a decrease in serum levels of calcitonin and vitamin D were noted. Pharmacotherapy of the disorders of mineral metabolism contributed to a favorable course of the postoperative and rehabilitation periods of sialolithiasis treatment, and also reduced the frequency of the stone recurrence.


1. Delli K., Spijkervet F. K., Vissink A. Salivarygland diseases: infections, sialolithiasis and mucoceles. Monogr. Oral Sci. 2014;24:135-148. https://doi.org/10.1159/000358794
2. Lastivka A. S., Tisevich L. I. Sljunnokamennaja bolezn’: ucheb.-metod. posobie. Minsk: BSMU, 2014. (In Russ.).
3. Lim E. H., Nadarajah S., Mohamad I. Giant submandibular calculus eroding oral cavity mucosa. Oman Med. J. 2017;32(5):432-435. https://doi.org/10.5001/omj.2017.81
4. Gadve V., Mohite A., Bang K., Shenoi S. R. Unusual giant sialolith of Wharton’s duct. Indian J. Dent. 2016;7(3):162-164. https://doi.org/10.4103/0975-962X.174594
5. Balin V. N., Zolotukhin S. J. The experience of organ-sparing surgical treatment of sialolithiasis using veloscope. Stomatologija. – Stomatology. 2017;96(1):46-50. (In Russ.). https://doi.org/10.17116/stomat201796146-50
6. Zhmud M. V., Lobeyko V. V., Iordanishvili A. K. Salivary stone disease:
age-related changes in the composition and properties of mixed saliva, treatment with the use of minimally invasive technologies and prevention of recurrence. Kurskij nauchno-prakticheskij vestnik «Chelovek i ego zdorov’e». – Kursk scientific and practical bulletin «Man and his health». 2015;3:28-34. (In Russ.).
7. Dmitrienko E. V., Zabelin A. S. Modern ideas about the pathogenesis of salivary stone disease (literature review). Vestnik Smolenskoj medicinskoj akademii. – Bulletin of the Smolensk Medical Academy. 2010;2:46-48. (In Russ.).
8. Afanasiev V. V., Mirzakulova U. R. Sljunnye zhelezy: bolezni i travmy: rukovodstvo dlja vrachej. Moscow: GEOTAR-Media, 2019. (In Russ.).
9. Martynov G. V. Localized and primarily multiple bilities. Kazanskij medicinskij zhurnal. – Kazan Medical Journal. 2000;81(1):36-37. (In Russ.).
10. Wu C. C., Hung S. H., Lin H. C, Lee C. Z., Lee H. C., Chung S. D. Sialolithiasis is associated with nephrolithiasis: a case-control study. Acta Otolaryngol. 2016;136(5):497-500. https://doi.org/10.3109/00016489.2015.1129068
11. Hung S. H., Lin H. C., Su C. H., Chung S. D. Association of sialolithiasis with cholelithiasis: a population-based study. Head Neck. 2016;38(4): 560-563. https://doi.org/10.1002/hed.23926
12. Chechina I. N., Semennikov V. I. Frequency of combination of salivary-stone and urolithiasis diseases and justification of the method of conservative treatment and prevention of sialolithiasis. Allergologija i immunologija. – Allergology and Immunology. 2009;10(1):131-132. (In Russ.).
13. Benevolenskaya L. I. Diagnostika, profilaktika i lechenie osteoporoza. M.: GJeOTAR-Media, 2010. (In Russ.). 1
4. Holick M. F. Vitamin D and health: evolution, biologic functions, and recommended dietary intakes for vitamin D. Clin. Rev. Bone Miner. Metab. 2009;7:2-19. https://doi.org/10.1007/978-1-60327-303-9_1
15. Benevolenskaya L. I. Osteoporosis: the problem of osteoporosis in modern medicine (the role of calcium in the prevention of osteoporosis). Consilium medicum: zhurnal dokazatel’noj mediciny dlja praktikujushhih vrachej. – Consilium medicum: An evidence-based journal for medical practitioners. 2004;2:96-99. (In Russ.).
16. Rastogi A., Bhadada S. K., Bhansali A. Pseudoarthrosis and fracture: interaction between severe vitamin D deficiency and primary hyperparathyroidism. Singapore Med. J. 2013;54(11):224-227. https://doi.org/10.11622/smedj.2013093
17. Rudenko E. V., Buglova A. E., Rudenko E. V., Samohovets O. Yu. Medikamentoznoe lechenie osteoporoza u vzroslyh: uch.-metod. posobie. Minsk: BelMAPO, 2011. (In Russ.).
18. Mosekilde L. Vitamin D and the elderly. Clin. Endocrinol. (Oxf.). 2005;62(3):265-281. https://doi.org/10.1111/j.1365-2265.2005.02226.x
19. Diehl J. W., Chiu M. W. Effects of ambient sunlight and photoprotection on vitamin D status. Dermatol. Ther. 2010;23(1):48-60. https://doi.org/10.1111/j.1529-8019.2009.01290.x
20. Springbett P., Buglass S., Young A. R. Photoprotection and vitamin D status. J. Photochem. Photobiol. B. 2010;101(2):160-168. https://doi.org/10.1016/j.jphotobiol.2010.03.006
21. Rizzoli R., Boonen S., Brandi M. L., Bruyère O., Cooper C. [et al.]. Vitamin D supplementation in elderly or postmenopausal women: a 2013 update of the 2008 recommendations from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Curr. Med. Res. Opin. 2013;29(4):305-313. https://doi.org/10.1185/03007995.2013.766162
22. Heaney R. P., Dowell M. S., Hale C. A., Bendich A. Calcium absorption varies within the reference range for serum 25-hydroxyvitamin D. J. Am. Coll. Nutr. 2003;22(2):142- 146. https://doi.org/10.1080/07315724.2003.10719287
23. Holick M. F., Chen T. C. Vitamin D deficiency: a worldwide problem with health consequences. Am. J. Clin. Nutr. 2008;87(4):1080-1086. https://doi.org/10.1093/ajcn/87.4.1080S

Keywords: salivary stone disease, sialolithiasis, concrementectomy, mineral metabolism

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy