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https://doi.org/10.14300/mnnc.2020.15033

Morbihan disease. Rare clinical case

[Notes from practice]
Marianna Borisovna Drozhdina;

The article presents the description of a rare, under-studied dermatological disease accompanied by bright clinical symptoms – Morbihan’s disease. Data on epidemiology, etiology and pathogenesis of this disease, hypotheses of pathological process development are presented. The author considered the theories of gastrointestinal vasoactive peptides (vasoactive intestinal peptide, pentagastrin), mediator substances (endorphins, bradykinin, substance P), immunological component in combination with local lymphatic disorders participation in the pathogenesis. The dynamics of the disease, clinical picture, differential diagnosis, including histology of the pathological process, has been described in detail. Special attention is paid to treatment with antibiotics, membrane stabilizers, carbon dioxide laser, plasmapheresis, clofazimine, isotretinoin. The author describes an archive case of successful treatment of Morbigan disease using a long-term isotretinoin application.

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Keywords: Morbihan disease, rosacea, solid edema of perivascular dermis, isotretinoin, ketotifen