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https://doi.org/10.14300/mnnc.2022.17045

Possibilities for assessing stimulation of bone tissue regeneration in the background of experimental stress

[Experimental medicine]
Sergey Sirak; Evgeny Shchetinin; Roman Romanenko;

The results of an X-ray assessment of the dynamics of bone regeneration of postoperative defects in an experiment on rats using a stress-inducing device to form non-physiological occlusion of the jaws are presented. More effective and complete restoration of the alveolar ridge after tooth extraction was shown in animals treated intraperitoneally with ethylmethylhydroxypyridine succinate under chronic stress conditions. X-ray analysis of the bone regeneration confirmed the stimulation of bone healing by the drug in terms of 30 and 60 days in the form of filling the defect with trabecular bone, which, in terms of quantitative and qualitative composition, can provide the function of a scaffold for newly formed vessels and nerves.

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Keywords: radiography, experiment, osseointegration, chronic stress