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Однонуклеотидные полиморфизмы генов цитокинов и их роль в патогенезе сердечных, сосудистых и легочных заболеваний

[Обзор]
Пирожков Сергей Викторович; Перегуд Данил Игоревич; Теребилина Наталья Николаевна; Литвицкий Петр Францевич; Кабаева Екатерина Николаевна;

Проведен анализ современных данных о влиянии полиморфизмов генов цитокинов на возникновение, течение, проявления и исходы наиболее распространенных сердечных, сосудистых и легочных заболеваний человека, в патогенезе которых воспаление играет существенную роль. Спектр рассматриваемых цитокинов включает классы, потенцирующие воспалительный процесс (провоспалительные цитокины), такие как TNF-α, IL-1, IL-6, IL-12, IL-13, IL-17 и IL-33, и ингибирующи его (антивоспалительные), которыми считают IL-10, IL-4, TGF-β. Обсуждается роль полиморфизмов цитокинов в развитии дилятационной кардиомиопатии, ишемической болезни сердца, сердечной недостаточности, инсульта, бронхиальной астмы, хронической обструктивной болезни легких. Полученные данные свидетельствуют, что содержание и выраженность эффекта на патологический процесс полиморфизмов генов цитокинов зависят от локализации полиморфного участка, его влияния на экспрессию гена, от комбинации аллелей полиморфизмов и этнической принадлежности пациентов.

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Ключевые слова: цитокины, однонуклеотидный полиморфизм, дилятационная кардиомиопатия, ишемическая болезнь сердца, инсульт, ревматоидный артрит, бронхиальная астма, хроническая обструктивная болезнь легких


Учредители:
Ставропольская государственная медицинская академия
Государственный научно-исследовательский институт курортологии
Пятигорская государственная фармацевтическая академия