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of the North Caucasus
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ISSN 2073-8137

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Comparative characteristics of renin-angiotensine system gene polymorphism in children with chronic kidney disease of different stages

Rustem Zakievich Akhmetshin; Rasim Mazgarovich Shigapov; Irek Zigangaleevich Latypov; Petr Mironov;

The frequencies of alleles and genotypes of polymorphic loci of angiotensin receptor 1 (AGTR1, rs5186 (1166A/C)), angiotensin-converting enzyme (ACE, (Ins-Del)) receptor of angiotensin the second type (AGTR2, -1332A/G, rs1403543 (G1675A)), angiotenzinogen (AGT, rs4762 (Thr174Met)) were studied in 95 children. No association of CKD progression with ACE and AGT genes polymorphisms was found out. Children with end-stage CKD were carriers of the mutant forms AGTR1 and AGTR2. In cases of CKD of the second stage and above, a significant increase in the carriage of the C allele of the polymorphic variant of the AGTR1 gene was noted.


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Keywords: chronic kidney disease, children, genes of renin-angiotensin system, polymorphism

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy