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ISSN 2073-8137

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Broncho-provocative tests in diagnosis of bronchorectic disorders in patients with gastroesophageal reflux disease

[Original research]
Nabi Ummatovich Chamsutdinov; Aikhali Hamidovna Taygibova; Kubatay Masuev; Ali Azhubovich Huseynov;

In 121 patients with endoscopically positive form of gastroesophageal reflux disease (GERD) the functional state of the bronchial receptors was studied using inhalation bronchial provocation tests. Acetylcholine powders, injectable forms of dinoprost (prostaglandin F2α) and propranolol were inhaled as bronchiactivators in increasing dosages until a threshold dose was reached, leading to a decrease in FEV1 by 20 % and 35 %. In a third of patients with GERD, both cholinergic, adrenergic and prostaglandin bronchial hypersensitivity was detected. Bronchial hyperreactivity was detected in more than half of the patients studied. Cholinergic and prostaglandin hyperreactivity of the bronchi was mainly detected, less frequently adrenergic. Thus, we have concluded that bronchoobstructive disorders in patients with GERD are carried out through cholinergic and prostaglandin mechanisms.


1. Osler W. The Principles of Internal Medicine. New York: Appleton and Co., 1893. Available at: www.babel.hathitrust.org/cgi/pt?id=coo.31924105912848;view=1up;seq=14. Accessed November 15, 2018.
2. Taygibova A. G., Chamsutdinov N. U., Abdulmanapova D. N., Akhmedova P. N., Khanzaeva R. M. [et al.]. Mechanisms of the development of bronchial hyperreactivity. Sovremennye naukoemkie tehnologii. – Modern science-intensive technologies. 2010;2:115-117. (In Russ.).
3. Abdulmanapova D. N., Chamsutdinov N. U. Bronchopulmonary manifestations of gastroesophageal reflux disease: features of pathogenesis, clinic and diagnostics. Sovremennye problemy nauki i obrazovaniya. – Modern problems of science and education. 2013;(2). Available at: www.science-education.ru/108-8611. Accessed September 24, 2018. (In Russ.).
4. Morice A. H. Airway reflux as a cause of respiratory disease. Breathe. 2013;9(4):256-266. https://doi.org/10.1183/20734735.000513
5. Statman B. S. Is there really a link between asthma and reflux? 2017. Available at: www.clinicalcorrelations. org/2018/02/27/is-there-really-a-link-between-asthmaand-reflux/. Accessed November 29, 2018.
6. Global Strategy for Asthma Management and Prevention. 2018. 160 p. Available at: ginasthma.org/2018-gina-reportglobal-strategy-for-asthma-management-and-prevention/.Accessed September 25, 2018.
7. Riscili B. P., Parsons J. P., Mastronarde J. G. Treating silent reflux disease does not improve poorly controlled asthma. Cleveland Clin. J. Med. 2010;77(3):155-160. https://doi.org/10.3949/ccjm.77a.09111
8. Yu L., Xu X., Chen Q., Liang S., Lv H., Qiu Z. Gastro-esophageal reflux induced cough with airway hyperresponsiveness. Int. J. Clin. Exp. Med. 2014;7(3):728-735. Available at: www.ijcem.com/files/ijcem1401008.pdf.Accessed November 10, 2018.
9. Karbasi A., Ardestani M. E., Ghanei M., Harandi A. A. The association between reflux esophagitis and airway hyperreactivity in patients with gastro-esophageal reflux. J. Res.Med. Sci. 2013;18(6):473-476. Available at: www.ncbi.nlm.nih.gov/pmc/articles/PMC3818615/. Accessed November 14, 2018.
10. Clinical issues comorbidities. National Asthma Council Australia. 2015. Available at: www.asthmahandbook.org.au/uploads/575a504e7017c.pdf. Accessed November 15,2018.
11. Ates F., Vaezi M. F. Insight into the relationship between gastroesophageal reflux disease and asthma. Gastroenterol. Hepatol. 2014;10(11):729-736. Available at: www.ncbi.nlm.nih.gov/pmc/articles/PMC5395714/.Accessed November 25, 2018.
12. Eugenia Y. Interplay between asthma and gastroesophageal reflux disease: A controversial issue. Archives of asthma, allergy and immunology. 2017;2:6-7. https://doi.org/10.29328/journal.aaai.10010111
13. Pomari C., Mauroner L., Paiano S., Assante L. R., Bertolaccini L. [et al.]. Bronchial reacutization and gastroesophageal reflux: is there a potential clinical correlation? Annals of Translational Medicine. 2016;4(16):304. https://doi.org/10.21037/atm.2016.08.40
14. Emilsson Ö. I., Benediktsdóttir B., Ólafsson Í., Cook E., Júlíusson S. [et al.]. Respiratory symptoms, sleepdisordered breathing and biomarkers in nocturnal gastroesophageal reflux. Respiratory Research. 2016;17(1). https://doi.org/10.1186/s12931-016-0448-y
15. Agarwal A., Rishi J. P., Gupta A. N., Bhandari V. M. Histamine bronchoprovocation tests in subjects with gastro-oesophageal reflux disease. The Journal of the Association of Physicians of India. 1990;38:159-161. Available at: www.biomedsearch.com/nih/Histaminebronchoprovocation-tests-in-subjects/2380136.html. Accessed October 28, 2018.
16. Amarasiri D. L., Pathmeswaran A., de Silva H. J., Ranasinha C. D. Response of the airways and autonomic nervous system to acid perfusion of the esophagus in patients with asthma: a laboratory study. BMC Pulmonary Medicine. 2013;13(1):33. https://doi.org/10.1186/1471-2466-13-33

Keywords: gastroesophageal reflux disease, bronchoprovocation tests, acetylcholine, prostaglandin F2α, propranolol, bronchial hypersensitivity, bronchial hyperreactivity

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy