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In 121 patients with endoscopically positive form of gastroesophageal reflux disease (GERD) the functional state of the bronchial receptors was studied using inhalation bronchial provocation tests. Acetylcholine powders, injectable forms of dinoprost (prostaglandin F2α) and propranolol were inhaled as bronchiactivators in increasing dosages until a threshold dose was reached, leading to a decrease in FEV1 by 20 % and 35 %. In a third of patients with GERD, both cholinergic, adrenergic and prostaglandin bronchial hypersensitivity was detected. Bronchial hyperreactivity was detected in more than half of the patients studied. Cholinergic and prostaglandin hyperreactivity of the bronchi was mainly detected, less frequently adrenergic. Thus, we have concluded that bronchoobstructive disorders in patients with GERD are carried out through cholinergic and prostaglandin mechanisms.
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Keywords: gastroesophageal reflux disease, bronchoprovocation tests, acetylcholine, prostaglandin F2α, propranolol, bronchial hypersensitivity, bronchial hyperreactivity