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The impact of glucose-lowering therapy on quality of life indicators was studied in 200 patients with gastroesophageal reflux disease (GERD). Group I consisted of 50 patients with type 2 diabetes mellitus in combination with obesity and GERD treated by metformin. Group II consisted of 50 patients with type 2 diabetes mellitus in combination with obesity GERD treated by exenatide. Group III consisted of 50 patients suffering from obesity of GERD, group IV – of 50 patients with GERD without comorbidities. Omeprazole was used for treatment of GERD in all studied groups. The most positive influence on the quality of life after 6 months of treatment was observed in GERD, as well as in GERD plus obesity. In patients with GERD and type 2 diabetes mellitus the best results were observed in the group of exenatide.
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Keywords: gastroesophageal reflux disease, obesity, type 2 diabetes mellitus, hypoglycemic therapy, quality of life