logo
Medical news
of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137
rus
русский
eng
english

Site search



Correspondence address
310 Mira Street, Stavropol, Russia, 355017

Tel
+7 8652 352524; +7 8652 353229.

Fax
+7 8652 352524.

E-mail
medvestnik@stgmu.ru

Effect of glucose-lowering therapy on quality of life in patients with diabetes mellitus type 2, gastroesophageal refluxe disease and obesity

[Original research]
Elena Andreeva;

The impact of glucose-lowering therapy on quality of life indicators was studied in 200 patients with gastroesophageal reflux disease (GERD). Group I consisted of 50 patients with type 2 diabetes mellitus in combination with obesity and GERD treated by metformin. Group II consisted of 50 patients with type 2 diabetes mellitus in combination with obesity GERD treated by exenatide. Group III consisted of 50 patients suffering from obesity of GERD, group IV – of 50 patients with GERD without comorbidities. Omeprazole was used for treatment of GERD in all studied groups. The most positive influence on the quality of life after 6 months of treatment was observed in GERD, as well as in GERD plus obesity. In patients with GERD and type 2 diabetes mellitus the best results were observed in the group of exenatide.

Download

References:
1. Bardymova T. P., Berezina M. V., Mikhaleva O. G. Prevalence of obesity in patients with diabetes mellitus in Irkutsk. Sibirsky meditsinsky zhurnal. – Siberian Medical Journal. 2013;121(6):130-132. (In Russ.).
2. Kryuchkova O. N., Shahbazidi D., Shahbazidi G. Leptin – a key link in the pathogenesis of obesity. Krymsky terapevtichesky zhurnal. – Crimean Journal of Internal Diseases. 2012;(1):31-36. (In Russ.).
3. Lapteva I. V., Livzan M. A. Optimization of therapy of gastroesophageal reflux disease in persons with obesity and overweight. Sovremennye problemy nauki i obrazovaniya. – Modern problems of science and education. 2016;(2):29. (In Russ.).
4. Khan A., Kim A., Sanossian C. Impact of obesity treatment on gastroesophageal reflux disease. World J. Gastroenterol. 2016;22(4):1627-1638.
5. Punjabi P., Hira A., Prasad S. Review of gastroesophageal reflux disease (GERD) in the diabetic patient. J. Diabetes. 2015;7(5):599-609.
6. Korneeva N. V., Fedorchenko Yu. L., Bogatkov S. D. Features of the course of gastroesophageal reflux disease in diabetes mellitus. Sibirsky meditsinsky zhurnal. – Siberian Medical Journal. 2011;26(3-1):57-61. (In Russ.).
7. Ates F., Francis D. O., Vaezi M. F. Refractory gastroesophageal reflux disease: advances and treatment. Expert Rev. Gastroenterol. Hepatol. 2014;8(6):657-667.
8. Zvenigorodskaya L. A., Khomeriki S. G., Shinkin M. V. Gastroesophageal reflux disease in patients with obesity: clinical, functional and morphological features. Doctor. Ru. 2017;(2):46-52. (In Russ.).

Keywords: gastroesophageal reflux disease, obesity, type 2 diabetes mellitus, hypoglycemic therapy, quality of life


Founders:
Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy