Medical news
of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137

Site search

Correspondence address
310 Mira Street, Stavropol, Russia, 355017

+7 8652 352524; +7 8652 353229.

+7 8652 352524.


Effect of endothelium dysfunction on hemostasis in patients after coronary bypass

[Original research]
Irina Fedorovna Shlyk; Roman Valentinovich Sidorov; Sergey Vladimirovich Shlyk;

In patients with coronary artery disease who underwent coronary artery bypass surgery, hemostasis was assessed before intervention and 6 months after. The relationship of the identified changes with the level of endothelin-1 in serum was determined. Assessment of hemostasis was performed by thrombodynamic, the level of endothelin-1 was determined using enzyme immunoassay. An increase in the thrombogenic potential of blood plasma and the level of endothelin-1 in serum was established in patients with coronary artery disease before CABG. 6 months after CABG in patients with an unfavorable outcome, the preservation of hypercoagulation and the positive association of these changes with an increased level of endothelin-1 were revealed. The results of this work can be used to optimize the conservative treatment of coronary artery disease in patients after CABG, in order to prevent complications.


1. Bokerija L. A., Milievskaja E. B., Kudzoeva Z. F., Prjanishnikov V. V. Serdechno-sosudistaja hirurgija – 2017. Bolezni i vrozhdennye anomalii sistemy krovoobrashenija. M.: NMICSSH im. A.N. Bakuleva, 2018. (In Russ.).
2. Akchurin R. S., Shirjaev A. A., Vlasova Je. E., Vasil’ev V. P., Galjautdinov D. M. Surgical treatment of IHD. Russkij medicinskij zhurnal. – Russian medical journal. 2014;30:21-52. (In Russ.).
3. Atmadzas K. A., Komok V. V., Bunenkov N. S., Pjagaj V. A., Grinenko O. A. [et al.]. The role of genetic markers of thrombophilia in the development and thrombosis after coronary artery bypass surgery. Regionarnoe krovoobrashhenie i mikrocirkuljacija. – Regional blood circulation and microcirculation. 2016;15(1):4-10. (In Russ.).
4. Moncada S. Endothelium and cardiovascular diseases. Vascular Biology and Clinical Syndromes. 2018;5-10. https://doi.org/10.1016/B978-0-12-812348-5.00001-5
5. Mayyas F., Al-Jarrah M., Ibrahim K., Mfady D., Van Wagoner D. R. The significance of circulating endothelin-1 as a predictor of coronary artery disease status and clinical outcomes following coronary artery catheterization. Cardiovasc. Pathol. 2015;24(1):19-25. https://doi.org/10.1016/j.carpath.2014.08.004
6. Sin’kov S. V., Zabolotskih I. B. Diagnostika i korrekcija sistemy gemostaza. M.: Prakticheskaja medicina, 2017. (In Russ.).
7. Pi X., Xie L., Patterson C. Emerging Roles of Vascular Endothelium in Metabolic Homeostasis. Circ. Res. 2018;123(4):477-494. https://doi.org/10.1161/CIRCRESAHA.118.313237
8. Shlyk I. F., Sizjakina L. P., Kastanajan A. A., Sidorov R. V., Martirosov V. Ju., Shlyk S. V. The modern view of the assessment of vasoreactivity in patients with acute coronary syndrome. Vestnik nacional’nogo medikohirurgicheskogo centra im. N. I. Pirogova. – Bulletin of the National Medical and Surgical Center. N. I. Pirogov. 2016;11(3):88-92. (In Russ.).
9. Wang Т., Butany J. Pathogenesis of atherosclerosis. Diagn. Histopath. 2017;23(11):473-478. https://doi.org/10.1016/j.mpdhp.2017.11.009
10. Galjautdinov G. S., Chudakova E. A. Features of the hemostatic system in patients with ischemic disease. Kazanskij medicinskij zhurnal. – Kazan medical journal. 2012;93(1):3-7. (In Russ.).
11. Nomokonova E. A., Elykomov V. A., Efremushkina A. A., Anan’ev D. A. Hemostatic system parameters in patients with chronic coronary artery disease before and after coronary artery bypass surgery. Medicinskij al’manah. – Medical almanac. 2016;42(2):31-34. (In Russ.).
12. Dow C. A., Templeton D. L., Lincenberg G. M., Greiner J. J., Stauffer B. L., DeSouza C. A. Elevations in C-reactive protein and endothelin-1 system activity in humans. Life Sci. 2016;159:66-70. https://doi.org/10.1016/j.lfs.2015.12.030
13. Vnukov V. V., Sidorov R. V., Miljutina N. P., Ananjan A. A., Gvaldin D. Ju. [et al.]. Content of proinflammatory cytokines, peroxiredoxin-1 and glutathione-peroxidase activity in the blood plasma of IHD patients who underwent coronary artery bypass surgery. Uspehi gerontologii. – The successes of gerontology. 2017;2:269-274. (In Russ.).

Keywords: thrombodynamics, endothelin-1, coronary bypass

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy