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Relationship of metabolic syndrome with adhesion molecules in non-alcoholic fatty liver disease

[Original research]
Pavel Koroy; Sergey Slyadnev; Alexandr Yagoda;

Relationship of adhesion molecules with features of metabolic syndrome was studied in 208 patients with nonalcoholic fatty liver disease (NAFLD). Maximal values of ICAM-1 and VCAM-1 in blood were observed in cases of abdominal obesity or disorders of lipid metabolism. Hyperinsulinemia or hyperglycemia were characterized by increased levels of VCAM-1 and PECAM-1 in patients with NAFLD. Combination of NAFLD with insulin resistance or with arterial hypertension was accompanied by raised levels of all adhesion molecules. Metabolic syndrome was associated with disbalance of intercellular mediators as elevation of concentration of ICAM-1, VCAM-1, and PECAM 1 with increase in quantity of criteria of metabolic syndrome. Levels of ICAM-1 more than 848 ng/ml, VCAM-1 above 2355 ng/ml, PECAM-1 more than 70 ng/ml have been connected with the increased chance of presence of metabolic syndrome in NAFLD.


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Keywords: non-alcoholic fatty liver disease, metabolic syndrome, adhesion molecules

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy