Site search
Correspondence address
310 Mira Street, Stavropol, Russia, 355017
Tel
+7 865 2352511, +7 865 2353229.
E-mail
medvestnik@stgmu.ru
The journal is included into The list of leading scientific periodicals.
The journal is included into VINITI database and is registered in Electronic scientific library.
The journal is indexed by SCOPUS, Ulrich's International Periodicals Directory.
[Original research] [Dermatology]
Maria Arnautova;
Оbjective – to determine whether an additional ap-
pointment of Silimar is purposeful in patients with re-
fractory form of psoriasis receiving methotrexate.
127 patients with moderate to severe psoriasis were
included: 45 patients in the study group, 42 patients
in the second study group, 40 patients in the control
group.
Initially the study groups had comparable enzyme
activity (p> 0,05). After treatment all groups showed an
increase of transaminases activity. The maximal differ-
ence in the enzymes activity before and after the treat-
ment was revealed in the group of patients treated with
methotrexate. In the group of patients treated by Sili-
mar the increase of enzymes activity was similar to the
control group.
Normal activity of transaminases in patients treated
by Silimar suggests that its use is appropriate in pa-
tients with refractory form of psoriasis receiving metho-
trexate.
References:
1. Arnautova M.S. Aspirantsky vestnik Povolzhya. –
Postgraduate Journal of the Volga. 2012;5-6:13-16.
2. Koshkin C.B. Klinicheskaya dermatologiya i venero-
logiya. – Clinical Dermatology and Venereology.
2008;1:32-35.
3. Korotky N.G., Polyakova A.A. Consilium medicum:
zhurnal dokazatelnoy meditsiny dlya praktikuyushchikh
vrachey. – Consilium medicum. 2005:26.
4. Izmalkova M.S. (Arnautova M.S.) Prioritetnaya sprav-
ka o poluchenii patenta “Sposob lecheniya sredne-
tyazhelykh i tyazhelykh form psoriaza” ot 05.03.2012
№ 2012108273.
5. Kotelnikov G.P., Shpigel A.S. Meditsinskoye obrazovaniye
i professionalnoye razvitiye. – Medical education and
professional development 2012;1:43-50.
6. Kurkin V.A., Ryzhov V.M. Sozdaniye importzameshchay-
ushchikh gepatoprotektornykh i antiok-sidantnykh leka-
rstvennykh sredstv na osnove plodov rastoropshi pyatnis-
toy. Samara; 2006. P.157-158.
7. Kuranova N.Yu., Beloborodova E.I., Khardikova S.A.
Sibirsky vestnik gepatologii i gastroenterologii. –
Siberian Journal of Hepatology and Gastroenterology.
2006;20:149-150.
8. Boehncke W.H., Boehncke S. J Dtsch Dermatol Ges.
2008;6:622-625.
Keywords: psoriasis, methotrexate, Silimar, hepatotoxicity, evidence-based medicine, aspartate aminotransferase, alanine aminotransferase