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Medical news
of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137
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The protective effect of silimar in patients with psoriasis treated by methotrexate

[Original research] [Dermatology]
Maria Arnautova;

Оbjective – to determine whether an additional ap-
pointment of Silimar is purposeful in patients with re-
fractory form of psoriasis receiving methotrexate.
127 patients with moderate to severe psoriasis were
included: 45 patients in the study group, 42 patients
in the second study group, 40 patients in the control
group.
Initially the study groups had comparable enzyme
activity (p> 0,05). After treatment all groups showed an
increase of transaminases activity. The maximal differ-
ence in the enzymes activity before and after the treat-
ment was revealed in the group of patients treated with
methotrexate. In the group of patients treated by Sili-
mar the increase of enzymes activity was similar to the
control group.
Normal activity of transaminases in patients treated
by Silimar suggests that its use is appropriate in pa-
tients with refractory form of psoriasis receiving metho-
trexate.

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References:
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2008;1:32-35.
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ushchikh gepatoprotektornykh i antiok-sidantnykh leka-
rstvennykh sredstv na osnove plodov rastoropshi pyatnis-
toy. Samara; 2006. P.157-158.
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Sibirsky vestnik gepatologii i gastroenterologii. –
Siberian Journal of Hepatology and Gastroenterology.
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8. Boehncke W.H., Boehncke S. J Dtsch Dermatol Ges.
2008;6:622-625.

Keywords: psoriasis, methotrexate, Silimar, hepatotoxicity, evidence-based medicine, aspartate aminotransferase, alanine aminotransferase


Founders:
Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy