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Effect of chronic administration of haloperidol and risperidone on the number of dopamine receptors in rat brain tissue
[Abstracts]
Mariya Baturina; Eduard Beyer; Alexey Popov; Vladimir Baturin; Vladimir Baturin; Oleg Boev;
Long-term administration of neuroleptics of haloperidol and risperidone (0.1 mg/kg and 0.5 mg/kg) leads to an increase in the density of dopamine D1 receptors in the brain tissue of rats. The number of D2 receptors does not change significantly with haloperidol and decreases after the use of a high dose (0.5 mg/kg) of risperidone.
References:
1. Arushanyan E. B. Mechanisms of the antipsychotic effect of neuroleptics: problem state of the art. Eksperimental’naya i klinicheskaya farmakologiya. – Experimental and Clinical Pharmacology. 2008;71(5):52-57. (In Russ.). http://doi.org/10.30906/0869-2092-2008-71-5-52-57
2. Schwalbe T., Kaindl J., Hübner H., Gmeiner P. Potent haloperidol derivatives covalently binding to the dopamine D2 receptor. Bioorg. Med. Chem. 2017;25(19):5084-5094. http://doi.org/10.1016/j.bmc.2017.06.034
3. Xu H., Yang H. J., Rose G. M. Chronic haloperidol-induced spatial memory deficits accompany the upregulation of D(1) and D(2) receptors in the caudate putamen of C57BL/6 mouse. Life Sci. 2012;91(9-10):322-328. http://doi.org/10.1016/j.lfs.2012.07.025
4. Chopko T. C., Lindsley C. W. Classics in Chemical Neuroscience: Risperidone. ACS Chem. Neurosci. 2018;9(7):1520-1529. http://doi.org/10.1021/acschemneuro.8b00159
5. Hage C., Bédard A. M., Samaha A. N. Antipsychotic treatment leading to dopamine supersensitivity persistently alters nucleus accumbens function. Neuropharmacology. 2015;99:715-725. http://doi.org/10.1016/j.neuropharm.2015.03.012
Keywords: haloperidol, risperidone, dopamine receptors
Founders:
Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy