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ISSN 2073-8137

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Effect of chronic administration of haloperidol and risperidone on the number of dopamine receptors in rat brain tissue

Mariya Baturina; Eduard Beyer; Alexey Popov; Vladimir Baturin; Vladimir Baturin; Oleg Boev;

Long-term administration of neuroleptics of haloperidol and risperidone (0.1 mg/kg and 0.5 mg/kg) leads to an increase in the density of dopamine D1 receptors in the brain tissue of rats. The number of D2 receptors does not change significantly with haloperidol and decreases after the use of a high dose (0.5 mg/kg) of risperidone.


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Keywords: haloperidol, risperidone, dopamine receptors

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy