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Change in proliferative processes in thymus of rats affected by antenatal and postnatal influence of the dichlorodiphenyltrichlorethane endocrine disraptor

[Experimental medicine]
Natalya Valentinovna Yaglova; Elina Soslanovna Tsomartova; Sergey Stanislavovich Obernikhin; Svetlana Vladimirovna Nazimova; Valentin Vasilievich Yaglov; Elizaveta Chereshneva; Marina Ivanova; Sergey Kuznetsov;

A comprehensive immunohistochemical and radioisotope study of the proliferation of thymocytes in male Wistar rats that developed under the conditions of antenatal and postnatal exposure to low doses of dichlorodiphenyl trichloroethane endocrine disruptor was carried out at different periods of postnatal ontogenesis. It was found that the proliferation of thymocytes in newborn rats and rats in the suction period is lower than the control values. By puberty, the natural rate of decrease in proliferative activity becomes less pronounced, as a result of which proliferative processes in the thymus parenchyma proceed more actively, which indicates a change in the program of postnatal organ development by the endocrine disruptor.


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Keywords: thymus, endocrine disrupter, DDT, proliferation

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy