logo
Medical news
of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137
rus
русский
eng
english

Site search



Correspondence address
310 Mira Street, Stavropol, Russia, 355017

Tel
+7 8652 352524; +7 8652 353229.

Fax
+7 8652 352524.

E-mail
medvestnik@stgmu.ru

Histological studies of organs in experiment on the application of a niosomal form of anti-tumor medicine

[Experimental medicine]
Igor Bazikov; Alexander Maltsev; Valentina Botasheva; Alexander Aksenov; Alexander Kornienko; Violeta Korolkova; Filipp Bazikov;

The study of histological changes showed that encapsulation of the antitumor substance N-hydroxy-2-(2-(naphthalen-2-yl)-1H-indol-3-yl)-2-phenylacetamide in niosomes increases its cytotoxicity. This is due to the peculiarities of the pharmacokinetics of niosomal drugs. When the antitumor substance is encapsulated in niosomes, its metabolism is slower in the liver, and due to this the substance is in the peripheral blood for a longer time at higher concentrations compared to the introduction of the antitumor substance in its pure form.

Download

References:
1. Kornienko A., Mathieu V., Rastogi S., Lefranc F., Kiss R. Therapeutic agents triggering non-apoptotic cancer cell death. J. Med. Chem. 2013;56:4823-4839.
2. Bazikov I. A., Beyer E. V., Lukinova V. V., Maltsev A. N. Comparative evaluation of acute toxicity of doxorubicin and its niosomal form. Meditsinskii vestnik Severnogo Kavkaza. – Medical News of North Caucasus. 2015;10(4):403-406. (In Russ.).
3. Aksenov A. V., Smirnov A. N., Magedov I. V., Reisenauer M. R., Aksenov N. A. [et al.]. Activity of 2 Aryl-2-(3-indolyl) acetohydroxamatesagainst Drug-Resistant Cancer Cells. J. Med. Chem. 2015;58:2206-2220.
4. Aksenov A. V., Smirnov A. N., Aksenov N. A., Bijieva A. S., Aksenova I. V., Rubin M. Benzimidazoles and benzoxazoles via the nucleophilic addition of anilines to nitroalkanes. Organic & Biomolecular Chemistry. 2015;13:4289-4295.
5. Bazikov I. A., Beyer E. V., Maltsev A. N., Goptareva Ye. A., Malinina N. I. [et al.]. Investigation of the cardiotoxicity of the niosomal form of doxorubicin. Meditsinskii vestnik Severnogo Kavkaza. – Medical News of North Caucasus. 2016;11(3):421-424. (In Russ.).
6. Bazikov I. A., Maltsev A. N., Zelensky V. A., Korolkova V. I., Kalinkina N. I., GoptarevaYe. A. Antimicrobial activity of niosomal gel with doxorubicin in the complex treatment of melanoma of the maxillofacial region. Bacteriology. 2017;2(1):61-65. (In Russ.).

Keywords: pathomorphological changes, niosomal form of N-hydroxy-2-(2-(naphthalen-2-yl)-1H-indol-3-yl)-2-phenylacetamide, glioblastoma


Founders:
Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy