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https://doi.org/10.14300/mnnc.2019.14166

Histological studies of organs in experiment on the application of a niosomal form of anti-tumor medicine

[Experimental medicine]
Igor Bazikov; Alexander Maltsev; Valentina Botasheva; Alexander Aksenov; Alexander Kornienko; Violeta Korolkova; Filipp Bazikov;

The study of histological changes showed that encapsulation of the antitumor substance N-hydroxy-2-(2-(naphthalen-2-yl)-1H-indol-3-yl)-2-phenylacetamide in niosomes increases its cytotoxicity. This is due to the peculiarities of the pharmacokinetics of niosomal drugs. When the antitumor substance is encapsulated in niosomes, its metabolism is slower in the liver, and due to this the substance is in the peripheral blood for a longer time at higher concentrations compared to the introduction of the antitumor substance in its pure form.

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References:
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Keywords: pathomorphological changes, niosomal form of N-hydroxy-2-(2-(naphthalen-2-yl)-1H-indol-3-yl)-2-phenylacetamide, glioblastoma