• Main page
• About the journal
• Editorial board
• Subscription
• Information for contributors
• Editorial and Peer Review
• Issues archive
• Authors
• Articles
  • By alphabet
  • By category
• Blogs and comments

The journal is included into The list of leading scientific periodicals.

The journal is included into VINITI database and is registered in Electronic scientific library.

The journal is indexed by SCOPUS, Ulrich's International Periodicals Directory.

EBSCO

https://doi.org/10.14300/mnnc.2019.14162

Clinical -morphological and immunohistochemical study of tissues during periimplantit and periodontitis

[Stomatology]
Anatoly Alekseevich Kulakov; Evgenia Kogan; Vladimir Nikolenko; Tatyana Vladislavovna Brailovskaya; Anna Petrovna Vedyaeva; Ekaterina Valeryevna Blinova;

A comparative clinical-morphological and immunohistochemical study of gum tissue with severe inflammatory
complications in the area of dental implants and teeth in patients with chronic generalized periodontitis was carried out. We studied 50 biopsy samples from 27 patients (14 women and 13 men) aged 35–60 years with diagnoses of peri-implantation mucositis (7 patients), peri-implantitis (14 patients), severe generalized periodontitis (6 patients). Immunohistochemical reactions with antibodies to Ki-67 (at a dilution of 1:100, Dako), VEGF (at a dilution of 1:100, Abcam), SMA (LabVision, at a concentration of 1:100) were performed on serial paraffin sections. It is established that when comparing chronic generalized periodontitis of severe degree and peri-implantitis, the latter is characterized by more pronounced inflammatory-destructive process in the implant area, caused by the addition of immune inflammation with the formation of a fibrous capsule around the implant. According to the data of immunohistochemical differences in SMA, VEGF, Ki-67, peri-implantation mucositis and peri-implantitis are successive stages of progression of one process.

Download

References:
1. Mombelli A., Müller N., Cionca N. The epidemiology of peri-implantitis. Clin. Oral. Implants. Res. 2012;23(6):67-76. https://doi.org/10.1111/j.1600-0501.2012.02541.x
2. Lang N. P., Berglundh T. Peri-implant diseases: where are we now? Consensus of the Seventh European Workshop on Periodontology. J. Clin. Periodontol. 2011;38(11):178-181. https://doi.org/10.1111/j.1600-051X.2010.01674.x
3. Lindhe J., Meyle J. Group D of European Workshop on Periodontology. Peri-implant diseases: consensus report of the sixth european workshop on periodontology. J. Clin. Periodontol. 2008;35(8):282-285. https://doi.org/10.1111/j.1600-051X.2008.01283.x
4. Berglundh T., Zitzmann N. U., Donati M. Are peri-implantitis lesions different from periodontitis lesions? J. Clin. Periodontol. 2011;38(11):188-202. https://doi.org/10.1111/j.1600-051X.2010.01672.x
5. Carcuac O., Berglundh T. Composition of human peri-implantitis and periodontitis lesions. J. Dent. Res. 2014;93:1083-1088. https://doi.org/10.1177/0022034514551754
6. Carcuac O., Abrahamsson I., Albouy J. P., Linder E., Larsson L., Berglundh T. Experimental periodontitis and peri-implantitis in dogs. Clin. Oral. Implants Res. 2013;24(4):363-371. https://doi.org/10.1111/clr.12067
7. Ghighi M., Llorens A., Baroukh B., Chaussain C., Bouchard P., Gosset M. Differences between inflammatory and catabolic mediators of peri-implantitis and periodontitis lesions following initial mechanical therapy: An exploratory study. J. Periodontal. Res. 2018;53(1):29-39. https://doi.org/10.1111/jre.12483
8. Raes M., D’hondt R., Teughels W., Coucke W., Quirynen M. A 5-year randomized clinical trial comparing minimally with moderately rough implants in patients with severe periodontitis. J. Clin. Periodontol. 2018;45(6):711-720. https://doi.org/10.1111/jcpe.12901
9. Wong R. L., Hiyari S., Yaghsezian A., Davar M., Casarin M. [et al.]. Early intervention of peri-implantitis and periodontitis using a mouse model. J. Periodontol. 2018;89(6):669-679. https://doi.org/10.1002/JPER.17-0541
10. Yu X., Hu Y., Freire M., Yu P., Kawai T., Han X. Role of toll-like receptor 2 in inflammation and alveolar bone loss in experimental peri-implantitis versus periodontitis. J. Periodontal. Res. 2018;53(1):98-106. https://doi.org/10.1111/jre.12492
11. Caton J., Armitage G., Berglundh T., Chapple I. L. C., Jepsen S. S. [et al.]. A new classification scheme for periodontal and peri-implant diseases and conditions Introduction and key changes from the 1999 classification. J. Clin. Periodontol. 2018;45:45(20):S1-S8. https://doi.org/10.1111/jcpe.12935
12. Blinova Е., Roshchin D., Kogan E., Samishina E., Demura T. [et al.]. Patient-derived non-muscular invasive bladder cancer xenografts of main molecular subtypes of the tumor for anti-pd-l1 treatment assessment. Cells. 2019;8(6):526. https://doi.org/10.3390/cells8060526
13. Knodell R. G., Ishak К. G., Black W. С., Chen T. S., Craig R. [et al.]. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology. 1981;1:431-435.
14. Gualini F., Berglundh T. Immunohisto-chemical characteristics of inflammatory lesions at implants. J. Clin. Periodontol. 2003;30(1):14-18.
15. Venza I., Visalli M., Cucinotta M., De Grazia G., Teti D., Venza M. Proinflammatory gene expression at chronic periodontitis and peri-implantitis sites in patients with or without type 2 diabetes. J. Periodontol. 2010;81(1):99-108. https://doi.org/10.1902/jop.2009.090358

Keywords: peri-implantation mucositis, peri-implantitis, growth zones, SMA, Ki-67, VEGF