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ISSN 2073-8137
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Evaluation of some indicators of the hemostasis system in nasal cavity lavages in different forms of chronic rinosinusitis

[Otorhinolaryngology]
Mikhail Ivanov; Navjil Tsybikov; Elena Vladimirovna Egorova; Natalia Ivanova;

In patients with chronic purulent rhinosinusitis and chronic purulent-polypous rhinosinusitis, a nasal secretion was collected. In the obtained material, coagulological activity, the effect of «recoil» of tissue factor (TF) by monocytes, as well as the level of aAb to thrombin were studied. It was established that the nasal secret contains procoagulant substances that canreduce the time of recalcification of donor plasma, thrombin and prothrombin time, and APTT. The main compound causing these shifts is TF synthesized by monocytes of the nasal mucosa. Lavages from the nasal cavity contain tissue plasminogen activator.

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Keywords: nasal secretion, tissue factor (also called platelet tissue factor, factor III), thrombin, rhinosinusitis


Founders:
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Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy