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Intrauterine infection verification by gray-scale echography for patients with preterm labor

[Obstetrios and gynecology]
Natalya Vladimirovna Krivonosova; Grigory Artemovich Penzhoyan; Olga Ivanovna Sikalchuk; Milena Aleksandrovna Penzhoyan; Victoria Valerievna Makukhina;

The informative value of the ultrasound assessment of the thymus in the diagnosis of intrauterine infection (IUI) was studied to increase the accuracy of the prediction of premature birth (PB). A retrospective study of 134 patients with menacing PR at 22–35 weeks of gestation was carried out. Clinical, laboratory, ultrasound signs of IUI were evaluated. The thymic-thoracic ratio (TTR) was used to evaluate the thymus. The information content of the signs for the PB forecast was estimated by the method of binary logistic regression with the construction of ROC-curves. The combination of TTR and premature rupture of the membranes (ROM) had the maximum diagnostic value for predicting PB (AUC=0.894±0.032; sensitivity (S)=82.1 %; specificity (Sp)=96.8 %; prognostic value of a positive test (VPT)=91.4 %; prognostic value of the negative test (VNT)=92.9 %). The combination of TTR, cervical length and echopositive sludge in amniotic fluid predicts PB in patients with IUI with S=84.6 %, Sp=89.5 %, VPT=82.1 %, VNT=93.4 %, AUC=0.860±0,034.

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Keywords: intrauterine infection, ultrasound examination, preterm labor, thymus, cervical length, sludge


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