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https://doi.org/10.14300/mnnc.2019.14149

Risk prediction of hypercoagulation complications after operation of portosystem bypass in patients with hepatic cirrhosis complicated by portal hypertension

[Surgery]
Natalia Germanovna Sapronova; Eleonora Vladimirovna Svetova; Roman Nikolaevich Kantsurov; Yulia Lukash; Maria Ruslanovna Kantsurova;

In recent years, more and more data have appeared in the literature on the presence of hypercoagulable syndrome in patients with cirrhosis of the liver, the diagnosis of which has its own peculiarities. The need for in-depth study of hemostasis in such patients is due to their risk of developing post-operative thrombotic complications that are life-threatening in nature. All known methods and ways of predicting and assessing the severity of patients with cirrhosis are aimed at assessing the degree of hepatic insufficiency and the risk of bleeding from varicose veins of the esophagus and stomach. In order to improve the postoperative prognosis, we developed a method for predicting the risk of hypercoagulable complications (Patent of the Russian Federation for invention № 2665118), based on the analysis of a set of specific data. The clinical material includes 31 patients with cirrhosis of the liver of a viral etiology complicated by portal hypertension, who underwent the TIPS. The proposed method made it possible to distribute patients to risk groups in order to determine the indications for the timely prescription of a preventive course of drug therapy.

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Keywords: transjugular intrahepatic portosystemic shunting, cirrhosis, portal hypertension, thrombodynamics, hemostasis