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[Infectious diseases]
Elena Kotenyova; Olga Tsygankova; Alexander Vasilievich Kalinin; Alena Vladimirovna Abramovich;
For the purpose of estimation of the genetic variety, a retrospective analysis of canSNP of 52 anthrax strains, isolated in the North Caucasus and in its adjacent territories over a period of 68 years from various materials during anthrax outbreaks is carried out. A considerable variability of SNP-loci has been shown. The most widespread and scarce SNP-genotypes and their quantitative and temporal distribution in the republics of the North Caucasus and in its adjacent territories have been revealed. A relation between the belonging of strains to the rare SNP-genotype B.Br001/002 which shows peculiarities in phenotypic properties of these cultures, and the role of populations of Bacillus anthracis strains of mixed pheno- and genotypes in the maintenance of pathogenicity potential under various conditions and in the reliability of their genetic marking during epidemiological investigation of anthrax outbreaks are being considered.
References:
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4. Tsygankova O. I., Eremenko E. I., Tsygankova E. A., Buravtseva N. P., Ryazanova A. G. Phenotypic and genetic peculiarities of cultural and morphological variants of Bacillus anthracis. Jurnal mikrobiologii, epidemiologii, immunobiologii. – Journal of microbiology, epidemiology and immunobiology. 2008;4:611. (In Russ.).
5. Sylvestre P., Couture-Tosi E. and M. Mock. Polymorphism in the collagen-like region of the Bacillus anthracis BclA protein leads to variation in exosporium filament length. J. Bacteriol. 2003;185:1555-1563. https://doi.org/10.1128/JB.185.5.1555-1563.2003
6. Sylvestre P., Moya M., Haustant M., Vaissaire J., Mock M. Carbohydrate Metabolism Differences between Subgroup A1 and B2 Strains of Bacillus anthracis as Assessed by Comparative Genomics and Functional Genetics. Appl. Environ. Microbiol. 2009;75(17):5727-5728. https://doi.org/10.1128/AEM.02715-08
7. Laboratornaya diagnostika opasnykh infektsionnykh boleznei. Prakticheskoye rukovodstvo. M.: ZAO «Shiko », 2013. (In Russ.).
8. Kulichenko A. N., Eremenko E. I., Ryazanova A. G., Aksenova L. Y., Kovalev D. A. [et al.]. Biological properties and molecular-geneticc haracteristics of Bacillus anthracis strains, isolated during the outbreak of anthrax in the Yamalo-Nenets autonomous districtin 2016. Problemy osobo opasnyh infekcij. – Problems of Particularly Dangerous Infections. 2017;(1):94-99. (In Russ). https://doi.org/10.21055/0370-1069-2017-1-94-99
Keywords: B. anthracis strains, SNP-genotype, phenotypic properties, heterogeneity of strain population, pidemiological investigation