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EBSCO

https://doi.org/10.14300/mnnc.2019.14132

Changes in the severity of haloperidol catalepsy in rats under chronic administration of neuroleptics

[Abstracts]
Mariya Baturina; Eduard Beyer; Olga Boeva; Alexey Popov;

In experiments on 80 laboratory rats, the change in the severity of catalepsy caused by the intraperitoneal administration of haloperidol at a dose of 2 mg/kg was assessed for chronic administration of antipsychotics to these animals (haloperidol 0.1 and 0.5 mg/kg and risperidone 0.1 and 0.5 mg/kg). After 15 and 30 days of administration of antipsychotics, catalepsy in rats was less pronounced than in control animals (administration of saline).

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Keywords: catalepsy, rats, antipsychotics, tolerance, haloperidol, risperidone