Medical news
of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137

Site search

Correspondence address
310 Mira Street, Stavropol, Russia, 355017

+7 8652 352524; +7 8652 353229.

+7 8652 352524.


Changes in the severity of haloperidol catalepsy in rats under chronic administration of neuroleptics

Mariya Baturina; Eduard Beyer; Olga Boeva; Alexey Popov;

In experiments on 80 laboratory rats, the change in the severity of catalepsy caused by the intraperitoneal administration of haloperidol at a dose of 2 mg/kg was assessed for chronic administration of antipsychotics to these animals (haloperidol 0.1 and 0.5 mg/kg and risperidone 0.1 and 0.5 mg/kg). After 15 and 30 days of administration of antipsychotics, catalepsy in rats was less pronounced than in control animals (administration of saline).


1. Arushanyan E. B., Psihofarmakologiya. V. 1. Stavropol, 2008.
2. Mironov A. N., Bunyatyan N. D., Vasilev A. N. Rukovodstvo po provedeniyu doklinicheskih issledovanij lekarstvennyh sredstv. Chast pervaya. Moscow: «Grif i K», 2012.
3. Chopko T. C., Lindsley C. W. Classics in Chemical Neuroscience:Risper-idone. ACS Chem. Neurosci. 2018;9(7):1520-1529. https://doi.org/10.1021/acschemneuro.8b00159
4. Li M. Antipsychotic-induced sensitization and tolerance: Behavioral characteristics, developmental impacts, and neurobiological mechanisms. J. Psychopharmacol. 2016;30(8):749-770. https://doi.org/10.1177/0269881116654697

Keywords: catalepsy, rats, antipsychotics, tolerance, haloperidol, risperidone

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy