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Medical news
of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137
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Changes in the severity of haloperidol catalepsy in rats under chronic administration of neuroleptics

[Abstracts]
Mariya Baturina; Eduard Beyer; Olga Boeva; Alexey Popov;

In experiments on 80 laboratory rats, the change in the severity of catalepsy caused by the intraperitoneal administration of haloperidol at a dose of 2 mg/kg was assessed for chronic administration of antipsychotics to these animals (haloperidol 0.1 and 0.5 mg/kg and risperidone 0.1 and 0.5 mg/kg). After 15 and 30 days of administration of antipsychotics, catalepsy in rats was less pronounced than in control animals (administration of saline).

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References:
1. Arushanyan E. B., Psihofarmakologiya. V. 1. Stavropol, 2008.
2. Mironov A. N., Bunyatyan N. D., Vasilev A. N. Rukovodstvo po provedeniyu doklinicheskih issledovanij lekarstvennyh sredstv. Chast pervaya. Moscow: «Grif i K», 2012.
3. Chopko T. C., Lindsley C. W. Classics in Chemical Neuroscience:Risper-idone. ACS Chem. Neurosci. 2018;9(7):1520-1529. https://doi.org/10.1021/acschemneuro.8b00159
4. Li M. Antipsychotic-induced sensitization and tolerance: Behavioral characteristics, developmental impacts, and neurobiological mechanisms. J. Psychopharmacol. 2016;30(8):749-770. https://doi.org/10.1177/0269881116654697

Keywords: catalepsy, rats, antipsychotics, tolerance, haloperidol, risperidone


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Pyatigorsk State Research Institute of Balneotherapeutics
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