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https://doi.org/10.14300/mnnc.2019.14126

Leukocytic responses in peripheral blood and peculiarities of bone marrow hematopoiesis in acute and chronic inflammation on a background of local removal of non-phagocytic granulocytes

[Experimental medicine]
Alla Sirak; Evgenia Ivanovna Piskareva; Oksana Gasamutdinovna Magomedova; Alina Pavlovna Arutyunova; Marina Dolgashova; Maria Olegovna Didenko; Natalia Andriutsa; Zuhra Magomedovna Kochkarova;

The aim of the present study was to investigate leukocytic responses in peripheral blood and the features of bone marrow hematopoiesis in acute and chronic inflammatory processes against a background of experimental localized removal of non-phagocytic granulocytes. Bone marrow hematopoiesis was assessed by calculating the total number of myelokaryocytes and the cellular composition of bone marrow obtained from the femurs of 24 male Wistar rats weighing 180–220 g. During the inflammatory process after prior localized removal of non-phagocytic granulocytes, hematopoiesis-especially lymphopoiesis-was enhanced, and there was a decrease in leukocyte counts from the bone marrow into the blood.

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References:
1. Ortega-Gómez A., Perretti M., Soehnlein O. Resolution of infl ammation: An integrated view. EMBO Molecular Medicine. 2013;5(5):661-674. https://doi.org/10.1002/emmm.201202382
2. Headland S. E., Norling L. V. The resolution of infl ammation:Principles and challenges. Seminars in Immunology. 2017;27(3):149-160. https://doi.org/10.1016/j.smim.2015.03.014
3. Moskalev A. V., Rudoy A. S., Apchel A. V., Shangin A. B. Role of neutrophilic granulocytes in the immunoinfl ammatory process. Vestnik Rossijskoj voenno-medicinskoj akademii. Bulletin of the Russian Military Medical Academy. 2016;(4):191-195.
4. Alexeeva N. T. The Participation of Cell Component in Regeneration of Wounds. Zhurnal anatomii i gistopatologii. Journal of Anatomy and Histopathology. 2014;3(1):9-15.
5. Wynn T. A., Vannella K. M. Macrophages in Tissue Repair, Regeneration, and Fibrosis. Immunity. 2016;44(3):450-462. https://doi.org/10.1016/j.immuni.2016.02.015
6. O’Sullivan J. A., Carroll D. J., Moreno-Vinasco L., Cao Y., Bochner B. S. [et al.] Frontline science: characterization of a novel mouse strain expressing human siglec-8 only on eosinophils. Journal of Leukocyte Biology. 2018;104(1):11-19. https://doi.org/10.1002/JLB.2HI0917-391R
7. Platzer B., Singer K., Panduro M., Lexmond W. S., Fiebiger E. [et al.] Dendritic cell-bound ige functions to restrain allergic inflammation at mucosal sites. Mucosal Immunology. 2015;8(3):516-532. https://doi.org/10.1038/mi.2014.85
8. Sugimoto M. A., Ribeiro A. L. C., Costa B. R. C., Vago J. P., Lima K. M. [et al.] Phagocytes, granulocytes, & myelopoiesis:Plasmin & plasminogen induce macrophage reprogramming & regulate key steps of inflammation resolution via annexin A1. Blood. 2017;129(21): 2896-2907. https://doi.org/10.1182/blood-2016-09-742825
9. Mosser D. M., Edwards J. P. Exploring the full spectrum of macrophage activation. Nature Reviews Immunology. 2008;8(12):958-969. https://doi.org/10.1038/nri2448
10. Breedveld A., van Egmond M., Kormelink T. G., de Jong E. C. Granulocytes as modulators of dendritic cell function. Journal of Leukocyte Biology. 2017;102(4):1003-1016. https://doi.org/10.1189/jlb.4MR0217-048RR
11. Uciechowski P., Rink L. Basophil, eosinophil, and neutrophil functions in the elderly. Immunology of Aging. 2014;10(1):47-63. https://doi.org/10.1007/978-3-642-39495-9_5
12. Cong Hong Hanh, Khaziakhmetova V. N., Ziganshina L. E. Modeling Inflammatory Edema: Are theиModels Interchangeable? Experimental’naya i klinicheskaya pharmakologiya. Experimetntal and Clinical Pharmacology.2015;78(7):24-31.
13. Zimatkin S.M. Histology. Minsk, 2014.

Keywords: acute inflammation, chronic inflammation, non-phagocytic granulocytes, experiment