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Genetic aspects of the development of myocardial remodeling in patients with type 2 diabetes mellitus

[Original research]
Elena V. Koroleva; Alexander Khokhlov; Alfiya M. Sirotkina; Olga G. Kozlova;

Currently, one of the prognostic criteria for the development of cardiovascular pathology in type 2 diabetes mellitus (DM) is the patient’s genetic characteristics. The study involved 258 patients with type 2 DM, of which 50 were carried out genetic testing with the study of polymorphisms of genes AGT:704, AGTR1:1166, GNB3:825, NOS3:–786, NOS3. The presence of remodeling in patients with DM is associated with an increase in the frequency of registration of NOS3:894 gene polymorphism in the form of a combination of mutation homozygotes and heterozygotes by 27.9 %, heterozygous polymorphism of this gene is associated with the identification of an unfavorable version of left ventricular myocardial remodeling concentric hypertrophy (p=0.04). A tendency to an increase in the frequency of the mutation-homozygotes of the gene GNB3:825 by 17.6 % and NOS3:–786 by 26.4 %, as for the heterozygotes of the AGT:704 gene polymorphism by 22.6 % and AGTR1:1166 by 16.7 %. As a result of our study revealed that the development of structural heart remodeling might be associated with polymorphism of genes encoding NOS3, as well as those responsible for the activity of the ACF: AGT, AGTR1, GNB3. Based on the results of genetic testing, it is possible to assess the prognosis of the disease and rationally select drug therapy, which helps to prevent the development of severe complications of DM.

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Keywords: gene polymorphism, type 2 diabetes mellitus, myocardial remodeling


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