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ISSN 2073-8137
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Corrective effect of angiotensin-converting enzyme inhibitors on the daily profile of blood pressure and somnological characteristics in elderly patients with combined cardiac pathology

[Original research]
Mikhail Osadchuk; Inna N. Vasil`eva; Ekaterina Mironova; Anastasia A. Khudarova; Nikolay Korzhenkov;

In recent years, a particular approach to the treatment of elderly patients with combined cardiac pathology has been gaining importance. It is aimed at adequate antihypertensive therapy and correction of chronologically occurring circadian biorhythms to study the curative effect of ramipril on the daily blood pressure (BP) profile and somnological characteristics of elderly patients with arterial hypertension (AH) and coronary artery disease (CAD). In an outpatient setting, 57 patients with the 1st and 2nd degree of stage III essential AH in combination with angina pectoris (AP) 1 and 2 functional class (FC) were examined. Patients underwent general clinical, laboratory examination, daily monitoring of blood pressure, somnological questionnaire survey. The study results allowed us to conclude that ramipril has a significant corrective effect on the regular BP profile and somnological characteristics in patients with combined cardiac pathology.

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Keywords: arterial hypertension, coronary artery disease, daily blood pressure profile, circadian biorhythms, somnological disorders


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Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy