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Folow up of skin testing with inhalation allergens in patients with comorbid allergic bronchial asthma and allergen-specific immunotherapy

[Internal diseases]
Elena Nadia; Valeriy Sovalkin; Galina Nechaeva; Ekaterina Loginova; Victor Goltyapin;

To assess the effect of allergen-specific immunotherapy (ASIT) on the parameters of specific allergic diagnostics with non-infectious allergens in patients with moderate allergic bronchial asthma, comorbid with allergic rhinitis and atopic dermatitis in the presence of polyvalent sensitization, a prospective, randomized controlled trial was conducted with 132 patients included. The first group of patients (n=88) against the background of basic anti-inflammatory therapy during the 3-year period had ASIT by four types of allergens identified during specific skin testing; the second group of patients (n=44) received only basic anti-inflammatory therapy. Analysis of the dynamics of the severity of skin-allergic samples showed that patients in the 1st group had significantly lower levels of pronounced tests and significant tests with an increase in the number of negative test results (p<0.005). By the end of the third year of observation, in the 2nd group of patients, the dynamics
towards a decrease in skin sensitivity to allergens was not detected.

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Keywords: bronchial asthma, allergic rhinitis, dermatitis, allergy, comorbidity, allergen-specific immunotherapy, antiinflammatory therapy, skin tests


Founders:
Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy