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ISSN 2073-8137
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Diagnostic significance of immunological markers with various forms of ulcerative colitis

[Internal diseases]
Alexandr Tkachev; Lilit Mkrtchyan; Rozaliya Belovolova; Tatiana Devlikamova;

A total of 44 patients with exacerbation of ulcerative colitis were examined. The study of immunological parameters (a subpopulation of lymphocytes, serum immunoglobulins, CIC, indicators of the metabolic activity of phagocytosis) revealed the associated nature of the severity of changes and the severity of relapse. A common pattern of the immune system response to exacerbation of ulcerative colitis was the development of immune system dysfunction in the form of an imbalance of lymphocyte subpopulations, disimmunoglobulinemia with an increase in IgM, CIC and a decrease in the metabolic activity of phagocytes, most pronounced in patients with severe colitis. The imbalance of lymphocyte subpopulations was manifested by an increase in the number of T lymphocytes with cytotoxic and apoptotic activity.
Impaired B-lymphocyte function was manifested by an increase in IgM, CIC and Ab levels of DNA and cardiolipin. The content of natural killers was disturbed, the adaptive reserves of phagocytic metabolic activity decreased. Established immunological indicators can be recommended as additional diagnostic criteria for the activity of ulcerative colitis and autoimmune component.

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Keywords: ulcerative colitis, innate and adaptive immunity, autoimmune inflammation, immunodiagnostics


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