logo
Medical news
of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137
rus
русский
eng
english

Site search



Correspondence address
310 Mira Street, Stavropol, Russia, 355017

Tel
+7 8652 352524; +7 8652 353229.

Fax
+7 8652 352524.

E-mail
medvestnik@stgmu.ru

Estimation of the level of anti-microbialp eptides in women of reproductive age with inflammatory diseases of the pelvic organs under the conditions of out-patient department

[Obstetrios and gynecology]
Roberta Boshyan; Vladimir Baturin;

The levels of antimicrobial peptides in 120 women of reproductive age with inflammatory diseases of the pelvic organs treated under polyclinic conditions were evaluated. Unlike the patients with minimal clinical symptoms of an infectious process, in which the level of α-defensin-1 in the blood was relatively low (21.1±6.5 ng/ml), although higher than normal values, and the content of β-defensin-1 (DEFb1) was high (75.6±14.4 ng/ml), severe clinical symptoms were accompanied by a high content of α-defensin-1 (46.5±12.5 ng/ml), and low β-defensin-1 (27.3±7.8 ng/ml).

Download

References:
1. Козлов Р. С. Устойчивость к антибиотикам как одна из основных проблем современного здравоохранения. Вестник Росздравнадзора. 2017;(4):28-33.
2. Martinez J. L., Baquero F. Emergence and spread of antibiotic resistance: setting a parameter space. Med. Sci. 2014;119(2):68-77. https://doi.org/10.3109/03009734.2014.901444
3. Петров Ю. А. Аспекты микробиологической и иммунной диагностики хронического эндометрита. Современные проблемы науки и образования. 2016;(4):9-10. https://doi.org/10.1177/1933719113508817
4. Sweet R. L. Pelvic Inflammatory Disease: Current Concepts of Diagnosis and Management. Curr. Infect. Dis. Rep. 2012;4:194-203. https://doi.org/10.18203/2320-1770.ijrcog20150097
5. Уткин Е. В., Кулавский В. А. Воспалительные заболевания органов малого таза у женщин. М.: ГЭОТАР-Медиа, 2015.
6. Батурин В. А., Болатчиев А. Д. Дефензины. Роль в патологии человека и перспективы применения. Вестник молодого ученого. 2016;(4):17-22.
7. Ивашова О. Н., Лебедева О. П., Пахомов С. П. Антимикробные пептиды в защите от инфекционных осложнений в акушерстве и гинекологии (обзор). Журнал акушерства и женских болезней. 2014;(5):81-89.
8. Sharma H., Tal R., Clark N. A. Microbiota and pelvic inflammatory disease. Sem. Reproduct. Med. 2014;32(1):43-49. https://doi.org/10.1055/s-0033-1361822
9. Furci L., Baldan R., Bianchini V. New role for human α-defensin 5 in the fight against hypervirulent Clostridium difficile strains. Infection and Immunity. 2015;83(3):986- 995. https://doi.org/10.1128/IAI.02955-14
10. Watt A. D., Perez K. A., Ang C. S. Peripheral α-defensins 1 and 2 are elevated in Alzheimer’s disease. J. Alzheimer’s Dis. 2015;44(4):1131-1143.
https://doi.org/10.3233/JAD-142286
11. 2018 European (IUSTI/WHO) Guideline on the Management of Vaginal Discharge. https://doi.org/10.1177/0956462418785451
12. Батурин В. А., Бошян Р. О. Изучение микробиоты урогенитального тракта женщин репродуктивного периода при воспалительных заболеваниях органов малого таза. Медицинский вестник Северного Кавказа. 2018;13(2):415-416. https://doi.org/10.14300/mnnc.2018.13065

Keywords: antimicrobial peptides, α-defensin, β-defensin, inflammatory diseases of the pelvic organs, microflora of the urogenital tract


Founders:
Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy