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Structural and metabolic changes in rat skeletal muscle after spinal cord injury

[Original research] [Experimental medicine]
Maxim Valerievich Stogov; Elena Anatolyevna Kireeva; Nadezhda Vladimirovna Kubrak;

The study was performed on 72 male Wistar rats. In the experimental group (n=24), lumbar spine modeling was performed after laminectomy. The animals of the control group (n=24) after laminectomy were sutured with an operating wound. Intact animals (n=24) did not undergo surgery. The activity of creatine phosphokinase, the concentration of lactate and the level of contractile proteins in the anterior tibial and soleus muscles were studied. It was found that after the spinal cord injury, the level of contractile proteins in both skeletal muscles of rats in the experimental group was reduced. In the anterior tibial muscle, a significant decrease in the level of contractile proteins was noted 5 days after injury. In the soleus muscle of the experimental group, the activity of creatine phosphokinase decreased significantly and the concentration of lactate increased. A significant increase in the level of lactate in the anterior tibial muscle was noted 180 days after the injury.

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Keywords: spinal cord injury, skeletal muscles, contractile proteins, energy metabolism


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