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Histological and immunohistochemical profile of bone tissue regenera tion under ultrafonophoresis of hyaluronic acid

[Original research] [Experimental medicine]
Sergey Sirak; Zuhra Magomedovna Kochkarova; Anton Andreev; Angela Balandina; Evgeny Shchetinin;

The article presents the results of histological and immunohistochemical studies of various stages of reparativeosteogenesis in the conditions of stimulation of regeneration along the fracture of the mandible by ultraphonophoresis with hyaluronic acid. The experiment was conducted on 36 year-old rabbits, divided into 2 equal groups, the main and control. The study revealed hematopoietic, mesenchymal, neural, ectodermal cell lines, indicating a stable growth of the reparative potential of the stem compartment of bone regenerate in the main group. Detection of these cells indicates the formation of physiological reparative regeneration and strengthening of cell proliferation and migration processes under the influence of ultraphonophoresis with hyaluronic acid, starting from the 20th day after the start of its use.

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Keywords: regeneration, bone, fracture, hyaluronic acid, ultraphonophoresis


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Pyatigorsk State Research Institute of Balneotherapeutics
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