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https://doi.org/10.14300/mnnc.2019.14021

Inhibiting influence of impulse magnetic fields and ionizing radiation on the culture of human T98G glioblastoma cells

[Original research] [Experimental medicine]
Ivan Aleksandrovich Popov; Alla Shikhliarova; Eduard Evgenievich Rostorguev; Marina Aleksandrovna Gusareva; Natalya Nikolaevna Timoshkina; Dmitry Sergeevich Potemkin; Julia Y. Arapova; Vitaly Viktorovich Stasov;

The maximal was observed in samples of T98G human glioblastoma cell culture after radiation exposure. Combination of ionizing radiation and impulse magnetic fields (IMF) with induction of 15 mT showed similarly high lethality values. Exposure to IMF alone with induction of 15 mT and 300 mT decreased the mitotic index by 3.6 and 2.4 times, respectively, and increased the culture lethality by 2.4–2.5 times compared to the control. The results demonstrate the inhibitory effect of impulse magnetic fields on the viability of malignant glial cells and the prospects of accompanying TMS therapy in neuro-oncology.

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Keywords: T98G glioblastoma, impulse magnetic field, ionizing radiation