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ISSN 2073-8137

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Inhibiting influence of impulse magnetic fields and ionizing radiation on the culture of human T98G glioblastoma cells

[Original research] [Experimental medicine]
Ivan Aleksandrovich Popov; Alla Shikhliarova; Eduard Evgenievich Rostorguev; Marina Aleksandrovna Gusareva; Natalya Nikolaevna Timoshkina; Dmitry Sergeevich Potemkin; Julia Y. Arapova; Vitaly Viktorovich Stasov;

The maximal was observed in samples of T98G human glioblastoma cell culture after radiation exposure. Combination of ionizing radiation and impulse magnetic fields (IMF) with induction of 15 mT showed similarly high lethality values. Exposure to IMF alone with induction of 15 mT and 300 mT decreased the mitotic index by 3.6 and 2.4 times, respectively, and increased the culture lethality by 2.4–2.5 times compared to the control. The results demonstrate the inhibitory effect of impulse magnetic fields on the viability of malignant glial cells and the prospects of accompanying TMS therapy in neuro-oncology.


1.Siegel R. L., Miller K. D., Jemal A. Cancer Statistics, 2017. CA: А Cancer Journal for Clinicians. 2017;67(1):7-30. https://doi.org/10.3322/caac.21387
2. Kaprin A. D., Starinskij V. V., Petrova G. V. (eds.). Zlokachestvennye novoobrazovaniya v Rossii v 2016 godu (zabolevaemost i smertnost). Moscow: MNIOI im. P. A. Gertsena; 2018. (In Russ.).
3. Pervichnye opukholi tsentralnoj nervnoj sistemy. Klinicheskie rekomendatsii ministerstva zdravookhraneniya Rossijskoj Federatsii; 2018. Available at: http://cr.rosminzdrav.ru/#!/recomend/853. Accessed December 19, 2018. (In Russ.).
4. Zhu P., Zhu J. J. Tumor treating fields: a novel and effective therapy for glioblastoma: mechanism, efficacy, safety and future perspectives. Chinese Clinical Oncology. 2017;6(4):41. https://doi.org/10.21037/cco.2017.06.29
5. Ulashchik V. S. Magnet therapy: current understanding of mechanisms of magnet field action on body. Zdravookhranenie. – Health care. 2015;11:21-29. (In Russ.).
6. Kutashov V. A., Shulga A. S. Transcranial magnetic therapy in neurological clinic. Tsentralnyj nauchnyj vestnik. – Central Scientific Herald. 2016;1(12):9-11. (In Russ.).
7. Falone S., Grossi M. R., Cinque B., D’Angelo B., Tettamanti E. [et al.]. Fifty hertz extremely low-frequency electromagnetic field causes changes in redox and differentiative status in neuroblastoma cells. The International Journal of Biochemistry & Cell Biology. 2007;39(11):2093-2106. https://doi.org/10.1016/j.biocel.2007.06.001
8. Destefanis M., Viano M., Leo C., Gervino G., Ponzetto A. [et al.]. Extremely low frequency electromagnetic fields affect proliferation and mitochondrial activity of human cancer cell lines. International Journal of Radiation Biology. 2015;91(12):964-972. https://doi.org/10.3109/09553002.2015.1101648
9. Marchesi N., Osera C., Fassina L., Amadio M., Angeletti F. [et al.]. Autophagy Is Modulated in Human Neuroblastoma Cells Through Direct Exposition to Low Frequency Electromagnetic Fields. Journal of Cellular Physiology. 2014;229(11):1776-1786. https://doi.org/10.1002/jcp.24631
10. Storch K., Dickreuter E., Artati A., Adamski J., Cordes N. BEMER Electromagnetic Field Therapy Reduces Cancer Cell Radioresistance by Enhanced ROS Formation and Induced DNA Damage. PLoS One. 2016;11(12):e0167931. https://doi.org/10.1371/journal.pone.0167931

Keywords: T98G glioblastoma, impulse magnetic field, ionizing radiation

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy