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Influence of cobalt chloride on calcium homeostasis and systemic hemodynamics under the conditions of experimental hypercalcemia

[Original research] [Experimental medicine]
David Khachaturovich Oganesyan;

The concentrations of ionized and total calcium of blood, calcium and cobalt in bone tissue, functional state of the cardiac vascular system was studied. Experimental hypercalcemia in rats was created by daily single administration of the drug «Aquadetrim» at a dose of 3000 IU/100 g and 10 % calcium chloride solution at a dose of 0.3 ml per 200 g of body weight. Cobalt chloride was administered intragastrically with a probe at a dose of 4 mg/kg. Studies have shown that intragastric administration of cobalt chloride caused the decalcification of bone tissue with the accumulation of cobalt in the bones, and changes in the parameters of systemic hemodynamics that manifested themselves in the form of arterial hypertension. Experimental hypercalcemia had some protective effect on the development of cobalt intoxication manifestations.

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Keywords: heavy metals, cobalt chloride, hemodynamics, hypercalcemia, rats


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