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Peculiarities of the perinatal period and the polymorphism of the genes of the prediction of thrombozem in adolescents with essential arterial hypertension

[Pediatrics]
Svetlana Bolshakova; Marina Gomellya; Tatiana Bairova; Olga Berdina; Olga Bugun; Lubov Rychkova;

The peculiarities of the perinatal period and their connection with the polymorphism of the genes of predisposition to thrombosis in 97 adolescents with essential arterial hypertension (EAH) were studied. The patients were divided into groups according to the presence/absence of prothrombotic changes (PC) of hemostasis. The group without PC was 60 teenagers, with PC – 37 teenagers. It was determined that patients with EAH and PC have the highest frequency of complications of the perinatal period. The association of C677T polymorphism of the 5,10-methylenetetrahydrofolate reductase gene with the development of PC in EAH is shown. The connection between the peculiarities of the perinatal period in adolescents with EAH and the polymorphism of the genes of predisposition to thrombosis was established. Among statistically significant carriers of risk genotypes C/T and T/T, statistically significant differences were obtained in such indicators as complicated pregnancy, the threat of interruption of the second half of pregnancy, late gestosis, chronic intrauterine hypoxia the fetus. Given multifactoriality of hemostasis changes in pediatric patients with cardiovascular pathology, it is necessary to continue conducting scientific research in this field to develop approaches to the prevention and treatment of such conditions from the standpoint of personalized medicine.

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Keywords: hemostasis, polymorphisms of genes, essential arterial hypertension, adolescents


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