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[Obstetrios and gynecology]
Artem Lukashevich; Victor Aksenenko; Alexander Dubovoy; Igor Nezhdanov; Ludmila Mozheiko; Igor Vasilyev;
Serum concentrations of cytotrophoblastic invasion markers MMP-9 and TIMP-1 were determined and the possibility of using them as placenta accreta predictors was evaluated. The study included 50 pregnant women with a diagnosis of «ingrowth of the placenta», 50 pregnant women with placenta previa without its ingrowth, the control group was 50 women with successfully proceeding pregnancy. In the study of serum concentrations of MMP-9, TIMP-1 a heterogeneous ELISA was used. Statistically significant data were obtained, allowing to refer MMP-9, TIMP-1 to serum predictors of pathological placental invasion. Critical values of the concentration of serum biomarkers, significantly correlated with the formation of placenta invasion, were determined. The ratio of serum concentration of MMP-9 to TIMP-1 differed in the groups of pregnant women with ingrowth of the placenta and with placenta previa without ingrowth.
References:
1. Heller D. S. Placenta Accreta and Percreta. Surgical Pathology Clinics. 2013;6(1):181-197. https://doi.org/10.1016/j.path.2012.10.003
2. Pan X. Y., Wang Y. P., Zheng Z. A Marked Increase in Obstetric Hysterectomy for Placenta Accreta. Chin. Med. J. 2015;128(16):2189-2193. https://doi.org/10.4103/0366-6999.162508
3. Davydov A. I., Agrba I. B., Voloshchuk I. N., Kilicheva I. I. Klinicheskaya otsenka ekspressii immunogistokhimicheskikh markerov v patogeneze vrastaniya platsenty. Voprosy ginekologii, akusherstva i perinatologii – Questions of gynecology, obstetrics and perinatology. 2013;(2):9-16. (In Russ.).
4. Jauniaux E., Jurkovic D. Placenta accreta: pathogenesis of a 20th century iatrogenic uterine disease. Placenta. 2012;33(4):244-251. https://doi.org/10.1016/j.placenta.2011.11.010
5. Aleksandrova N. V., Baev O. R. Ranniye etapy stanovleniya sistemy mat’-platsenta-plod. Akusherstvo i ginekologiya. – Obstetrics and gynecology. 2011;(8):4-10. (In Russ.).
6. Vodneva D. N., Shmakov R. G., Shchegolev A. I. Rol markerov invazii trofoblasta v razvitii preeklampsii i opukholevoĭ progressii. Akusherstvo i ginekologiya. – Obstetrics and gynecology. 2013;(11):9-12. (In Russ.).
7. Matjila M., Millar R., Van der Spuy Z., Katz A. The Differential Expression of Kiss1, MMP9 and Angiogenic Regulators across the Feto-Maternal Interface of Healthy Human Pregnancies: Implications for Trophoblast Invasion and Vessel Development. PLoS One. 2013;8(5):e63574. https://doi.org/10.1371/journal.pone.0063574
8. Su M. T., Tsai P. Y., Tsai H. L., Chen Y. C., Kuo P. L. MiR-346 and miR-582-3p-regulated EG-VEGF expression and trophoblast invasion via matrix metalloproteinases 2 and 9. Biofactors. 2017;43(2):210-219. https://doi.org/10.1002/biof.1325
9. Zhuang Y., Qian Z., Huang L. Elevated expression levels of matrix metalloproteinase-9 in placental villi and tissue inhibitor of metalloproteinase-2 in decidua are associated with prolonged bleeding after mifepristone-misoprostol medical abortion. Fertil Steril. 2014;101(1):166–171. https://doi.org/10.1016/j.fertnstert.2013.09.027
10. Kan N. E., Tyutyunnik V. L., Kesova M. I., Demura T. A., Sergunina O. A. [et al.]. Morfologicheskiye i immunogistokhimicheskiye osobennosti miometriya pri nedifferentsirovannoi displazii soyedinitel’noi tkani kak osnova razvitiya akusherskikh oslozhnenii. Akusherstvo i ginekologiya. – Obstetrics and gynecology. 2013;(10):28- 32. (In Russ.).
11. Ke Y., Lu J. H., Yang B. L., Guo H. Q., Ma Q. Y. [et al.]. Involvement of matrix metalloproteinase-2, -9, and tissue inhibitors of metalloproteinase-1, 2 in occurrence of the accrete placenta. Zhonghua Fu Chan Ke Za Zhi. 2006;41(5):311-314. https://doi.org/10.3760/j.issn:0529-567x.2006.05.007
12. Nissi R., Talvensaari-Mattila A., Kotila V., Niinimäki M., Järvelä I. [et al.]. Circulating matrix metalloproteinase MMP-9 and MMP-2/TIMP-2 complex are associated with spontaneous early pregnancy failure. Reprod. Biol. Endocrinol. 2013;15(11):2. https://doi.org/10.1186/1477-7827-11-2
13. Deng Q., Chen Y., Yin N., Shan N., Luo X. [et al.]. N-cetylglucosaminyltransferase V inhibits the invasion of trophoblast cells by attenuating MMP2/9 activity in early human pregnancy. Placenta. 2015;36(11):1291-1299. https://doi.org/10.1016/j.placenta.2015.08.014
Keywords: placenta accreta, matrix metalloproteinase-9 (MMP-9), inhibitor of matrix metalloproteinase-1 (TIMP-1), cytotrophoblast invasion, enzyme-linked immunosorbent assay