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The role of matrix metalloproteinase -9 and its tissue inhibitor (TIMP -1) as serum markers of placenta accrete

[Obstetrios and gynecology]
Artem Lukashevich; Victor Aksenenko; Alexander Dubovoy; Igor Nezhdanov; Ludmila Mozheiko; Igor Vasilyev;

Serum concentrations of cytotrophoblastic invasion markers MMP-9 and TIMP-1 were determined and the possibility of using them as placenta accreta predictors was evaluated. The study included 50 pregnant women with a diagnosis of «ingrowth of the placenta», 50 pregnant women with placenta previa without its ingrowth, the control group was 50 women with successfully proceeding pregnancy. In the study of serum concentrations of MMP-9, TIMP-1 a heterogeneous ELISA was used. Statistically significant data were obtained, allowing to refer MMP-9, TIMP-1 to serum predictors of pathological placental invasion. Critical values of the concentration of serum biomarkers, significantly correlated with the formation of placenta invasion, were determined. The ratio of serum concentration of MMP-9 to TIMP-1 differed in the groups of pregnant women with ingrowth of the placenta and with placenta previa without ingrowth.

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Keywords: placenta accreta, matrix metalloproteinase-9 (MMP-9), inhibitor of matrix metalloproteinase-1 (TIMP-1), cytotrophoblast invasion, enzyme-linked immunosorbent assay


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