logo
Medical news
of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137
rus
русский
eng
english

Site search



Correspondence address
310 Mira Street, Stavropol, Russia, 355017

Tel
+7 865 2352511, +7 865 2353229.

E-mail
medvestnik@stgmu.ru

Selectins as predictors of stable virologic clearance in chronic viral hepatitis C

[Original research] [Internal diseases]
Alexandr Yagoda; Pavel Koroy; Guzel Gilyazova;

Plasma levels of selectins were studied in 90 pa-
tients with chronic viral hepatitis C in relationship with
the results of antiviral therapy.
The levels of Е-, L- and Р-selectin in blood were
increased in patients with chronic viral hepatitis С.
The plasma levels of Е- and L-selectin decreased
and parameters of soluble P-selectin normalized
during antiviral therapy, especially in patients who
have reached sustained virologic response. The de-
velopment of sustained virologic response in chronic
viral hepatitis С is associated with lower initial blood
levels of Е- and Р-selectin that can be used in prog-
nosis of stable virologic clearance.

Download

References:
1. Galich, A. B. Osobennosti klinicheskogo techeniya,
dinamika tsitokinov i adgezinov pri protivovirusnom
lechenii khronicheskogo gepatita B u detey: Avtoref.
dis. … kand. med. nauk / Galich A. B. M., 2005. 27 p.
2. Koroy P. V., Yagoda A. V. Meditsinsky vestnik Severnogo
Kavkaza. – Medical News of North Caucasus. 2010;1:45-
50.
3. Koroy P. V., Yagoda A. V. Meditsinsky vestnik Severnogo
Kavkaza. – Medical News of North Caucasus. 2009;2:43-
48.
4. Koroy P. V., Yagoda A. V., Mukhoramova I. S. Meditsinsky
vestnik Severnogo Kavkaza. – Medical News of North
Caucasus. 2012;3:38-41.
5. Yagoda A. V., Koroy P. V. Ter. arkhiv. – Therapeutic
archive. 2004;8:72-75.
6. Berg T., Andreone P., Pol S. [et al.]. Hepatology.
2011;54:375A-376A.
7. Bruno C.M., Sciacca C., Cilio D. [et al.]. World.
J. Gastroenterol. 2005;11(29):4566-4569.
8. Geerts A.M., Cheung K.-J., Van Vlierberghe H. [et al.].
J. Hepatol. 2007;46(5):804-815.
9. George M.M., Li S.D., Mindikoglu A.L. [et al.] Platelet
sparing effect of COX II inhibition used with pegylated
interferon alfa-2a for the treatment of chronic hepatitis
C: a short term pilot study. Cytokine. 2004;27(6):159-
165.
10. Guzman-Fulgencio M., Berenguer J., de Castro I.F.
[et al.]. J. Antimicrob. Chemother. 2011;66:645-649.
11. Kцtter I., Koch S., Vonthein R. [et al.] Clin. Exp.
Rheumatol. 2005;23(4):20-26.
12. Kukla M., Zwirska-Korczala K., Gabriel A. [et al.]. Therap.
Adv. Gastroenterol. 2009;2(2):79-90.
13. Montalto G., Giannitrapani L., Soresi M. [et al.].
Inflammation. 2001;25(2):101-108.
14. Panasiuk A., Prokopowicz D., Panasiuk B. World.
J. Gastroenterol. 2004;10(24):3639-3642.
15. Panasiuk A., Zak J., Kasprzycka E. [et al.]. World.
J. Gastroenterol. 2005;11(18):2754-2758.
16. Panasiuk A., Prokopowicz D., Zak J. [et al.].
Hepatogastroenterol. 2004;51(59):1417-1421.
17. Sieghart W., Homoncik M., Jilma B. [et al.]. Thromb.
Haemost. 2006;95(2):260-266.
18. Stдttermayer A.F., Stauber R., Hofer H. [et al.]. Clin.
Gastroenterol. Hepatol. 2011;9(4):344-350.
19. Vardareli E., Saricam T., Demirusru C., Gulbas Z.
Hepatogastroenterol. 2007;54(74):466-469.
20. Wu S., Zhou X., Yang H. [et al.] Clin. Chem. Lab. Med.
2009;47(2):159-164.

Keywords: chronic viral hepatitis С, E-selectin, L-selectin, P-selectin, antiviral therapy, sustained virologic response


Founders:
Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy