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Atomic force microscopy of erythrocytes of patients with longerly non -healing wounds at the background of chronic venous failure

[Surgery]
Georgy Karapetyan; Ludmila Kochetova; Regina Pakhomova;

Long-term unhealed wounds of the lower extremities against the background of chronic venous insufficiency is a medical and socio-economic problem. The most radical method of pathology treating, which reduces the pressure on the walls of the veins, is surgery. The effective methods of conservative therapy aimed at the activation of reparative processes and the restoration of damaged tissues should include the method of local and systemic ozone therapy. The study included 48 patients who underwent a course of complex ozone therapy, including local effects on the wound and intravenous administration of ozonized autologous blood. At the background of complex ozone therapy, the structure of plasma membranes improved, the erythrocyte regained its shape, and the adhesive forces tended to normalize. Blood ozonization increased the flexibility of plasma membranes, restored the form of red blood cells.

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References:
1. Vinnik Ju. S., Karapetjan G. Je., Jakimov S. V., Sychev A. G. Use of cryogenic stimulation in treatment of chronic wounds. Vestnik hirurgii im. I. I. Grekova. – The messenger of surgery of I. I. Grekov. 2008;1:27-28. (In Russ.).
2. Kudykin M. N. Complex treatment of trophic ulcers. Flebologija. – Phlebology. 2008;3:16-20. (In Russ.).
3. Lucevich O. Je., Tamrazova O. B., Shikunova A. Ju. Modern view on a pathophysiology and treatment of purulent wounds. Hirurgija. – Surgery. 2011;5:72-77. (In Russ.).
4. Mironov V. I., Frolov A. P., Giljova I. I. The doctrine about wounds, history, development, prospects (part 1). Sibirskij medicinskij zhurnal. – Siberian medical magazin. 2010;4:118-122. (In Russ.).
5. Obolenskij V. N. Trophic ulcers of the lower extremities – the review of a problem. Rossijskij medicinskij zhurnal. – Russian medical magazine. 2010;4:28-55. (In Russ.).
6. Karapetjan G. Je. Treatment of patients with trophic ulcers. Vestnik hirurgii. – The messenger of surgery. 2014;173(3):72- 76. (In Russ.).
7. Moore K., Ruge F., Harding K.G. T-lymphocytes and the lack of activated macrophages in wound margin biopsies from chronic leg ulcers. Br. J. Dermatol. 2013;137(2):188- 194.
8. Novickij V. V. Atlas «Klinicheskij patomorfoz jeritrocita». Tomsk: Izd-vo Tomskogo un-ta; M.: Izdatel’skij Dom «GJeOTAR-MED»; 2003. (In Russ.).
9. Skorkina M. Ju., Chernjavskih S. D., Fedorova M. Z., Sladkova E. A., Zabinjakov N. A. Technique of assessment of morphometric parameters of native blood cells with use of atomic and power microscopy. Bjulleten’ jeksperimental’noj biologii i mediciny. – Bulletin of experimental biology and medicine. 2010;150(2):273-275. (In Russ.).
10. Vinnik Ju. S., Pahomova R. A., Kochetova L. V., Kozlov V. V. Hemilyuminestsentny activity and cytovery tectonics of neytrofilny granulocytes at patients with mechanical jaundice. Novosti hirurgii. – Surgery news. 2018;1:42-50. (In Russ.).
11. Pahomova R. A., Vinnik Ju. S., Kochetova L. V., Nagornov Ju. S. Morfofunktsionalny condition of erythrocytes at benign mechanical jaundice. Vestnik hirurgii im. I. I. Grekova. – The messenger of surgery of I. I. Grekov. 2017;4:22- 26. (In Russ.).
12. Gibson D. J., Schulftz G. Chronic wound diagnostic for matrix metalloproteinase. Wound healing Southern Africa. 2013;2(2):68-70.

Keywords: chronic venous insufficiency, atomic force microscopy of the erythrocyte ozonized autoblood


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