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ISSN 2073-8137
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The dynamics of levels of lypopolysaccharide-binding protein and procalcitonin during the experimental acute intestinal o bstruction

[Original research] [Experimental medicine]
Dana Amanova; Zhandos Koyshibaev; Lyudmila Akhmaltdinova; Dmitry Matyushko; Ermek Turgunov;

In this investigation the dynamics of bacteria translocation biomarkers during the experimental acute intestinal obstruction in rats were measured. The blood serum of 77 white Wistar rats with experimental model of intestinal obstruction was used for detecting of LBP and PCT on 1, 3, 5 and 7 days during acute intestinal obstruction. 2 groups of rats were included in this research: 1st – the rats with experimental model, 2nd – animals with Sham-operation. The level of procalcitonin was significantly increased on 1st day of obstruction, in comparison with baseline (p=0.01). In dynamics showing a statistically insignificant increase in intestinal obstruction in comparison with baseline values. The level of LBP in the experimental group during the experimental intestinal obstruction also increased in the first day, gradually decreasing by 5 and 7 days (p<0.05) with respect to the Sham group. Being an early marker of migration of bacterial agents through the intestinal wall, LBP can play the role as a predictor of septic complications. The level of procalcitonin, which increases in the early periods of disease and in dynamics grows up in the development of intestinal obstruction, is also a marker of the progressing of generalized septic complications and a systemic inflammatory reaction that arise during the evolution of intestinal obstruction in the experiment.

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Publication 15.02.2017. Bulletin № 278. (In Russ.)

Keywords: acute intestinal obstruction, biomarkers, procalcitonin, lypopolysaccharide-binding protein


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