• Main page
• About the journal
• Editorial board
• Subscription
• Information for contributors
• Editorial and Peer Review
• Issues archive
• Authors
• Articles
  • By alphabet
  • By category
• Blogs and comments

The journal is included into The list of leading scientific periodicals.

The journal is included into VINITI database and is registered in Electronic scientific library.

The journal is indexed by SCOPUS, Ulrich's International Periodicals Directory.

EBSCO

https://doi.org/10.14300/mnnc.2018.13140

Modern opportunities of magnetic -resonance technologies in diagnostics of the fatty liver

[Reviews]
Yanina Allakhverdieva; Sergey Vorobyev; Nikolai Mineev;

Тhe review summarizes the diagnostic capabilities of magnetic resonance tomography and proton magnetic resonance spectroscopy in patients with non-alcoholic fatty liver disease. The data on the accuracy and reproducibility of quantitative assessment of steatosis and liver fibrosis, the possibility of dynamic observation of patients with non-alcoholic fatty liver disease in high-field MRI with a double gradient echo in phase and antiphase, proton magnetic resonance spectroscopy and magnetic resonance elastography in a comparative aspect with liver biopsy are presented. It is concluded that the determination of the proton density of the fat fraction from the data of proton magnetic resonance spectroscopy or the quantitative assessment of the ratio of fat and water in magnetic resonance tomography is as close as possible to the «gold standard» of diagnosis.

Download

References:
1. Drapkina O. M., Gatsolaeva D. S., Ivashkin V. T. Non-alcoholic fatty liver disease as a component of the metabolic syndrome. Rossijskie medicinskie vesti. – Russian medical news. 2010;2:72-78 (In Russ.).
2. Vernon G., Baranova A., Younossi Z. M. Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment. Pharmacol. Ther. 2011;34:274-285.
3. Fracanzani A. L., Valenti L., Bugianesi E., Andreoletti M., Colli A. [et al.]. Risk of severe liver disease in NAFLD with normal aminotransferase levels: a role for insulin resistance and diabetes. Hepatology. 2008;48:792-798.
4. Gaggini M., Morelli M., Buzzigoli E., DeFronzo R. A., Bugianesi E., Gastaldelli A. Non-alcoholic fatty liver disease (NAFLD) and its connection with insulin resistance, dyslipidemia, atherosclerosis and coronary heart disease. Nutrients. 2013;5:1544-1560.
5. Armstrong M. J., Adams L. A., Canbay A., Syn W. K. Extrahepatic complications of nonalcoholic fatty liver disease. Hepatology. 2014;59:1174-1197.
6. Kropova O. E., Shindina T. S., Maksimov M. L. Non-alcoholic fatty liver disease: risk factors and pathogenetic therapy. RMZH. – RMZH.2016;26:1801-1804. (In Russ.).
7. Sharia M. A., Shiryaev G. A., Titov V. N., Ivanova K. V. The experience of non-invasive determination of fat concentration in the liver by magnetic resonance spectroscopy in hydrogen in patients with fatty hepatosis before and after treatment with Eslidine. Vestnik rentgenologii I radiologii. – Herald of radiology and radiology. 2013;2:50- 54 (In Russ.).
8. Sharia M. A., Shiryaev G. A., Ustyuzhanin D. V. Proton Magnetic Resonance Spectroscopy in a Diagnostic Algorithm in a Patient with Non-alcoholic Fat Liver Disease in an Integrated Approach to Treatment. REJR. 2014;4(3):91-93. (In Russ.).
9. Kropova O. E., Shindina T. S., Maksimov M. L. Non-alcoholic fatty liver disease: risk factors and pathogenetic therapy. RMZH. – RMZH. 2016;26:1801-1804. (In Russ.).
10. Tishkovsky S. V., Davydchik E. V., Nikonova L. V. Non-alcoholic fatty liver dis-ease and type 2 diabetes mellitus are links of one process. Zhurnal Grodnenskogo medicinskogo universiteta. – Journal of Grodno Medical University. 2016;1:92-98. (In Russ.).
11. Bannas P., Kramer H., Hernando D., Agni R., Cunningham A. M. [et al.]. Quantitative magnetic resonance imaging of hepatic steatosis: Validation in ex vivo human livers. Hepatology. 2015;62:1444-1455.
12. Bohte A. E., van Werven J. R., Bipat S., Stoker J. The diagnostic accuracy of US, CT, MRI and 1H-MRS for the evaluation of hepatic steatosis compared with liver biopsy: a meta-analysis. Eur. Radiol. 2011;21:87-97.
13. Bydder M., Shiehmorteza M., Yokoo T., Sugay S., Middleton M. S. [et al.]. Assessment of liver fat quantification in the presence of iron. Magn. Reson. Imaging. 2010;28:767-776.
14. Bonekamp S., Tang A., Mashhood A.,Wolfson T., Changchien C. [et al.]. Spatial distribution of MRI-Determined hepatic proton density fat fraction in adults with nonalcoholic fatty liver disease. J. Magn. Reson. Imaging. 2014;39:1525-1532.
15. Ratziu V., Bellentani S., Cortez-Pinto H., Day C., Marchesini G. A position statement on NAFLD/NASH based on the EASL 2009 special conference. J. Hepatol. 2010;53:372- 384.
16. Chen J., Talwalkar J. A., Yin M., Glaser K. J., Sanderson S. O., Ehman R. L. Early detection of nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease by using MR elastography. Radiology. 2011;259:749-756.
17. El-Hassan A. Y., Ibrahim E. M., Al-Mulhim F. A., Nabhan A. A., Chammas M. Y. Fatty infiltration of the liver: analysis of prevalence, radiological and clinical features and influence on patient management. Br. J. Radiol. 1992;65:774-778.
18. Grove A., Vyberg B., Vyberg M. Focal fatty change of the liver. A review and a case associated with continuous ambulatory peritoneal dialysis. Virchows Arch. 1991;419:69-75.
19. Larson S. P., Bowers S. P., Palekar N. A., Ward J. A., Pulcini J. P., Harrison S. A. Histopathologic variability between the right and left lobes of the liver in morbidly obese patients undergoing Roux-en-Y bypass. Clin. Gastroenterol. Hepatol. 2007;5:1329-1332.
20. Machann J., Thamer C., Schnoedt B. Hepatic lipid accumulation in healthy subjects: a comparative study using spectral fat-selective MRI and volume-localized 1H-MR spectroscopy. Magn. Reson. 2006;55:913-917.
21. Merkle E. M., Nelson R. C. Dual gradient-echo in-phase and opposed-phase hepatic MR imaging: A useful tool for evaluating more than fatty infiltration or fatty sparing. Radiographics. 2006;26:1409-1418.
22. Guiu B., Cercueil J. MRI as the new reference standard in quantifying liver steatosis: the need for international guidelines. Gut. 2012;61:1369-1370.
23. Kang B. K., Yu E. S., Lee S. S., Lee Y., Kim N. [et al.]. Hepatic fat quantification: a prospective comparison of magnetic resonance spectroscopy and analysis methods for chemical-shift gradient echo magnetic resonance imaging with histologic assessment as the reference standard. Invest. Radiol. 2012;47:368-375.
24. Kuhn J. P., Hernando D., Munoz del Rio A., Evert M., Kannengiesser S. [et al.]. Effect of multipeak spectral modeling of fat for liver iron and fat quantification: correlation of biopsy with MR imaging results. Radiology. 2012;265:133-142.
25. Lee S. S., Park S. H. Radiologic evaluation of nonalcoholic fatty liver disease. World J. Gastroenterol. 2014;20(23):7392-7402.
26. Kleiner D. E., Brunt E. M., Van Natta M., Behling C., Contos M. J. [et al.]. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology. 2005;41:1313-1321.
27. Permutt Z., Le T. A., Peterson M. R., Seki E., Brenner D. A. [et al.]. Correlation between liver histology and novel magnetic resonance imaging in adult patients with non-alcoholic fatty liver disease – MRI accurately quantifies hepatic steatosis in NAFLD. Aliment. Pharmacol. Ther. 2012;36:22-29.
28. Tang A., Tan J., Sun M., Hamilton G., Bydder M. [et al.]. Nonalcoholic fatty liver disease: MR imaging of liver proton density fat fraction to assess hepatic steatosis. Radiology. 2013;267:422-431.
29. Idilman I. S., Aniktar H., Idilman R., Kabacam G., Savas B. [et al.]. Hepatic steatosis: quantification by proton density fat fraction with MR imaging vs. liver biopsy. Radiology. 2013;267:767-775.
30. Idilman I. S., Keskin O., Celik A., Savas B., Halil Elhan A. [et al.]. A comparison of liver fat content as determined by magnetic resonance imaging-proton density fat fraction and MRS vs. liver histology in non-alcoholic fatty liver disease. Acta Radiol. 2016;57:271-278.
31. Negrete L. M., Middleton M. S., Clark L., Wolfson T., Gamst A. C. [et al.]. Inter-examination precision of magnitude-based MRI for estimation of segmental hepatic proton density fat fraction in obese subjects. J. Magn. Reson. Imaging. 2014;39:1265-1271.
32. Tyagi A., Yeganeh O., Levin Y., Hooker J. C., Hamilton G. C. [et al.]. Intra- and inter-examination repeatability of magnetic resonance spectroscopy, magnitudebased MRI, and complex-based MRI for estimation of hepatic proton density fat fraction in overweight and obese children and adults. Abdom. Imaging. 2015;40:3070-3077.
33. Noureddin M., Lam J., Peterson M. R., Middleton M., Hamilton G. [et al.]. Utility of magnetic resonance imaging vs. histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials. Hepatology. 2013;58:1930-1940.
34. Le T. A., Chen J., Changchien C., Peterson M. R., Kono Y. [et al.]. Effect of colesevelam on liver fat quantified by magnetic resonance in nonalcoholic steatohepatitis: a randomized controlled trial. Hepatology. 2012;56:922- 932.
35. Kim H., Taksali S. E., Dufour S., Befroy D., Goodman T. R. [et al.]. Comparative MR study of hepatic fat quantification using single-voxel proton spectroscopy, two-point Dixon and three-point IDEAL. Magn. Reson. Med. 2008;59:521-527.
36. Cassidy F. H., Yokoo T., Aganovic L. Fatty liver disease: MR imaging techniques for the detection and quantification of liver steatosis. Radiographics. 2009;29:231-260.
37. Chalasani N., Younossi Z., Lavine J. E., Diehl A. M., Brunt E. M. [et al.]. The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology. Gastroenterology. 2012;142:1592-1609.
38. Paparo F., Cenderello G., Revelli M., Bacigalupo L., Rutigliani M. [et al.]. Diagnostic value of MRI proton density fat fraction for assessing liver steatosis in chronic viral C hepatitis. Biomed. Res. Int. 2015;2015:1-11. https://doi.org/10/1155/2015/758164
39. Hamilton G., Middleton M. S., Bydder M., Yokoo T., Schwimme J. B. [et al.]. Effect of PRESS and STEAM sequences on magnetic resonance spectroscopic liver fat quantification. J. Magn. Reson. Imaging. 2009;30:145- 152.
40. Cowin G. J., Jonsson J. R., Bauer J. D., Ash S., Ali A. [et al.]. Magnetic resonance imaging and spectroscopy for monitoring liver steatosis. Magn. Reson. Imaging. 2008;28: 937-945.
41. Gulizia R., Ferraioli G., Filice C. Open questions in the assessment of liver fibrosis using real-time elastography. Am. J. Roentgenol. 2008;190:370-371.

Keywords: non-alcoholic fatty liver disease, magnetic resonance imaging, magnetic resonance spectroscopy, magnetic resonance elastography, diagnostic efficacy