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In 87 patients with chronic obstructive pulmonary disease (COPD) particularities of clinical-functional status, basic biochemical markers of systemic inflammation and their influence on the development of chronic kidney disease are studied. Chronic kidney disease was first diagnosed in 47.1% patients with COPD. It was found that severe course of COPD is accompanied by higher levels of inflammation markers. Comorbidity of COPD in respect to renal pathology with the development of CRF leads to significantly higher levels of CRP and TNF-α in the blood. The direct dependence of TNF-α and fibrinogen on the severity of chronic renal failure has been established. The indicators of TNF-α and CRP can serve as additional markers of impaired renal function in COPD.
1. Bolotova E. V., Dudnikova A. V. Particular risk factors for chronic kidney disease in patients with chronic obstructive pulmonary disease. Nefrologiya. – Nephrology. 2015;19(5):28-33. (In Russ.).
2. Chuchalin A. G., Avdeev S. N., Asanov Z. R., Belevskiy A. S., Leshchenko I. V., Meshcheryakova N. N., Ovcharenko S. I., Shmelev E. I. Russian respiratory society. Federal guidelines on diagnosis and treatment of chronic obstructive pulmonary disease. Pulmonologiya. – Pulmonology. 2014;3:15-54. (In Russ.). https://dx.doi.org/10.18093/0869-0189-2014-0-3-15-54
3. Bilichenko T. N., Bystritskaya E. V., Chuchalin A. G., Belevskiy A. S., Batyn S. Z. Mortality of respiratory disease in 2014–2015 and ways of its improvement. Pulmonologiya. – Pulmonology. 2016;26(4):389-397. (In Russ.). https://doi.org/10.18093/0869-0189-2016-26-4-389-397
4. Shestovitskiy V. A., Grinshteyn Y. I., Maksimova A. V. Cytological and oxidant characteristics of local cellular immunity in acute severe exacerbation of chronic obstructive pulmonary disease. Puimonologiya. – Pulmonology. 2017;27(4):478-483. (In Russ.). https://doi.org/10.18093/0869-0189-2017-27-4-478-483
Keywords: chronic obstructive pulmonary disease, chronic kidney disease, inflammation, biochemical markers