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Medical news
of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137
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Determination of the level of antibodies to melatonin 1A receptor in children with diabetes mellitus in different stages of the disease

[Abstracts]
Vladimir Baturin; Jury Bykov; Galina Mamceva; Tatyana Uglova; Rosa Yagudina;

Type I Diabetes mellitus (DM), or insulin-dependent diabetes, is the most common endocrine pathology among children and teenagers. The purpose of this study is to research the content of 1A melatonin receptor and antibodies to it in blood serum of children and teenagers. We examined 71 children and teenagers aged 1.9 to 17 years. We measured the content of 1A melatonin receptor and antibodies to it in hemolymph using an immunofluorescence assay test system (IFA). We found that the lowest levels of the 1A melatonin receptor were prevailing in children with a serious condition at the DM decompensation stage, median values were diagnosed in children in a state of moderate severity, and the maximum quantities are fixed in children against the background of the compensation of DM. The obtained data confirm the hypothesis about the possible involvement of the corpus pineale (epiphysis) in the pathogenesis of Type I Diabetes mellitus.

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References:
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2. Contreras-Alcantara S., Baba K., Tosini G. Removal of melatonin receptor type 1 induces insulin resistance in the mouse. Obesity. 2010;18(9):1861-1863. https://doi.org/10.1038/oby.2010.24
3. Mulder H., Nagorny C. L. F., Lyssenko V., Groop L. Melatonin receptors in pancreatic islets: good morning to a novel type 2 diabetes gene. Diabet. 2009;52(7):1240- 1249. https://doi.org/10.1007/s00125-009-1359-y
4. Sartori C. Melatonin improves glucose homeostasis and endothelial vascular function in high-fat diet-fed insulin resistant mice. Endocrin. 2009;150(12):5311-5317. https://doi.org/10.1210/en.2009-0425
5. Baturin V. A., Bykov Yu. V., Mamtseva G. I., Uglova T. А. Comparative analysis of antibodies to insulin receptors for children with type B insulin-dependent diabetes subject to the illness stage. Meditsinskii vestnik Severnogo Kavkaza. – Medical News of North Caucasus. 2016;11(1):80- 82. (In Russ.). https://doi.org/10.14300/mnnc.2016.11003

Keywords: insulin-dependent diabetes, melatonin receptors, auto-antibodies


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Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy