Medical news
of the North Caucasus
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ISSN 2073-8137

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Experimental therapy of changes of the circulation and content of electrolytes in cadmium intoxication

[Experimental medicine]
Vadim Brin; Karmen Mitziev; Oleg Kabisov; Astan Mitziev; Elmira Gagloeva;

The prolonged intake of cadmium into the body of experimental animals leads to the development of pronounced changes in systemic hemodynamics, accompanied by significant shifts in the concentrations of the main trace elements of the blood. Emerging arterial hypertension is caused by a sharp increase in peripheral vascular resistance, while cardiac output is significantly reduced. The accumulation of cadmium in bone tissue is combined with its decalcification. The content of total calcium and protein in the blood plasma decreases, and ionized calcium increases. Melatonin, used in the conditions of cadmium poisoning, has a significant therapeutic effect.


1. Brin V. B., Mitciev A. K., Mitciev K. G. Sposob korrekcii nefrotoksicheskogo dejstvija kadmija v jeksperimente. Vestnik novyh medicinskih tehnologij. – Bulletin of new medical technologies. 2011;18(2):194-195. (In Russ.).
2. Mitciev A. K., Brin V. B., Mitciev K. G. Korrekcija melaksenom izmenenij processov svobodnoradikal’nogo okislenija i kardiotoksicheskogo dejstvija kadmija v jeksperimente. Vestnik novyh medicinskih tehnologij. – Bulletin of new medical technologies. 2013;20(2):400-402. (In Russ.).
3. Järup L., Berglund M., Elinder C. G., Nordberg G., Vahter M. Health effects of cadmium exposure-a review of the literature and a risk estimate. Scand. J. Work Environ. Health. 1998;24(1):1-51.
4. Muneko N., Kowit N., Dhitiwass S. Gender-Specific Impact of Cadmium Exposure on Bone Metabolism in Older People Living in a Cadmium-Polluted Area in Thailand. Int. J. Environ. Res. Public. Health. 2017;14(4). https://doi.org/10.3390/ijerph14040401
5. Kukongviriyapan U., Apaijit K., Kukongviriyapan V. Oxidative stress and cardiovascular dysfunction associated with cadmium exposure: beneficial effects of curcumin and tetrahydrocurcumin. Tohoku. J. Exp. Med. 2016;239(1):25- 38. https://doi.org/10.1620/tjem.239.25
6. Brin V. B., Zonis B. Ja. Fiziologija sistemnogo krovoobrashhenija. Formuly i raschety. 1984. (In Russ.).
7. Brin V. B., Mitciev K. G., Mitciev A. K. Vlijanie jeksperimental’noj giperkal’ciemii na kardiovaskuljarnye projavlenija hronicheskoj mednoj intoksikacii. Vestnik novyh medicinskih tehnologij. – Bulletin of new medical technologies. 2014;21(2):83-86. (In Russ.).

Keywords: cardiovascular system, arterial hypertension, calcium, cadmium sulfate, melaxen

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy