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Analysis of magnetic resonance imaging of skeletal muscles and functional abilities in patients with Duchenne muscular dystrophy

[Neurology]
Dmitriy Ivanov; Vasilii Suslov; Dmitry Rudenko; Alexander Pozdnyakov; Galina Suslova; Alexandra Suslova;

Due to necessity of objective methods of assessing the state of skeletal muscles in patients with Duchenne muscular dystrophy, the aim was to determine the correlation between the Motor Function Measure (MFM) and the magnetic resonance imaging (MRI) data of the muscles of pelvic girdle, thighs and lower legs. 21 patients with Duchenne muscular dystrophy have been examined. Patients were divided into ambulant and non-ambulant groups. All patients have been evaluated by MFM scale and then MRI of skeletal muscles of the pelvic girdle, thighs and lower legs has been done. Ambulant patients have been characterized by a high negative correlation between D1 dimension and MRI data of the pelvic girdle and thighs muscles, as well as the total score of MRI scores and a moderate negative correlation between the MRI of the leg muscles. D2 and D3 also showed a moderate negative correlation with MRI results. Non-ambulant patients showed a high negative correlation only between D3 dimension and lower leg muscle MRI data, as well as the moderate negative correlation between the MFM total score and the sum of the pelvic girdle, thighs and lower legs MRI score. Magnetic resonance tomography is a more objective method for assessing muscle evaluation in ambulant and non-ambulant patients with Duchenne muscular dystrophy and can be a method of choice in assessing of severity of skeletal muscle changes.

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Keywords: Duchenne muscular dystrophy, magnetic resonance imaging


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