310 Mira Street, Stavropol, Russia, 355017
+7 8652 352524; +7 8652 353229.
+7 8652 352524.
The journal is included into The list of leading scientific periodicals.
Due to necessity of objective methods of assessing the state of skeletal muscles in patients with Duchenne muscular dystrophy, the aim was to determine the correlation between the Motor Function Measure (MFM) and the magnetic resonance imaging (MRI) data of the muscles of pelvic girdle, thighs and lower legs. 21 patients with Duchenne muscular dystrophy have been examined. Patients were divided into ambulant and non-ambulant groups. All patients have been evaluated by MFM scale and then MRI of skeletal muscles of the pelvic girdle, thighs and lower legs has been done. Ambulant patients have been characterized by a high negative correlation between D1 dimension and MRI data of the pelvic girdle and thighs muscles, as well as the total score of MRI scores and a moderate negative correlation between the MRI of the leg muscles. D2 and D3 also showed a moderate negative correlation with MRI results. Non-ambulant patients showed a high negative correlation only between D3 dimension and lower leg muscle MRI data, as well as the moderate negative correlation between the MFM total score and the sum of the pelvic girdle, thighs and lower legs MRI score. Magnetic resonance tomography is a more objective method for assessing muscle evaluation in ambulant and non-ambulant patients with Duchenne muscular dystrophy and can be a method of choice in assessing of severity of skeletal muscle changes.
1. Sussman M. Duchenne muscular dystrophy. J. Am. Acad. Orthop. Surg. 2002;10:138-151.
2. Emery A. E. The muscular dystrophies. Lancet. 2002;359(9307):687-695. https://doi.org/10.1016/S0140-6736(02)07815-7
3. Bushby K., Connor E. Clinical outcome measures for trials in Duchenne muscular dystrophy: report from International Working Group meetings. Clin. Investig. (Lond). 2011;1(9):1217-1235.https://doi.org/10.4155/cli.11.113
4. Godi C., Ambrosi A., Nicastro F. Longitudinal MRI quantification of muscle degeneration in Duchenne muscular dystrophy. Ann. Clin. Transl. Neurol. 2016;3(8):607-622. https://doi.org/10.1002/acn3.319
5. Scott E., Mawson S. J. Measurement in Duchenne muscular dystrophy: considerations in the development of a neuromuscular assessment tool. Dev. Med. Child. Neurol. 2006;48:540-544. https://doi.org/10.1017/S0012162206001137
6. Montes J., Gordon A. M., Pandya S., De Vivo D. C., Kaufmann P. Clinical outcome measures in spinal muscular atrophy. J. Child. Neurol. 2009;24:968-978. https://doi.org/10.1177/0883073809332702
7. Berard C., Payan C., Hodgkinson I., Fermanian J. The MFM Collaborative Study Group. A motor functional measure scale for neuromuscular disease. Construction and validation study. Neuromuscul. Disord. 2005;15:463-470. https://doi.org/10.1016/j.nmd.2005.03.004
8. Alfano L. N., Lowers L. P., Berry K. M., Yin H., Dvorchik I., Flanigan K. M., Cripe L., Mendell J. R. Pilot Study evaluating motivation on the performance of times walking in boys with Duchenne muscular dystrophy. Neuromuscul Disord. 2014;24(9-10):860. https://doi.org/10.1016/j.nmd.2014.06.224
9. Scott C. Cuthbert., George J., Goodheart Jr. On the reliability and validity of manual muscle testing: a literature review. Chiropr. Osteopat. 2007;15:4. https://doi.org/10.1186/1746-1340-15-4
10. Finanger E. L., Russman B., Forbes S. C. Use of skeletal muscle MRI in diagnosis and monitoring disease progression in Duchenne Muscular Dystrophy. Phys. Med. Rehabil. Clin. N. Am. 2012;23(1):1-IX. https://doi.org/10.1016/j.pmr.2011.11.004
11. Prompers J. J., Jeneson J. A., Drost M. R., Oomens C. C., Strijkers G. J., Nicolay K. Dynamic MRS and MRI of skeletal muscle function and biomechanics. NMR in Biomedicine. 2006;19(7):927-953. https://doi.org/10.1002/nbm.1095
12. Mercuri E., Talim B., Moghadaszadeh B., Petit N., Brockington M., Counsell S. Clinical and imaging findings in six cases of congenital muscular dystrophy with rigid spine syndrome linked to chromosome 1p (RSMD1). Neuromuscular Disord.: NMD. 2002;12(7-8):631-638. https://doi.org/10.1016/S0960-8966(02)00023-8
13. Schmidt S., Hafner P., Klein A. Timed function tests, motor function measure, and quantitative thigh muscle MRI in ambulant children with Duchenne muscular dystrophy: A cross-sectional analysis. Neuromuscular Disord. 2018;28(1):16-23. https://doi.org/10.1016/j.nmd.2017.10.003
14. Brooke M., Fenichel G. M., Griggs R. C. Clinical investigation in Duchenne dystrophy: 2. determination of the «power» of therapeutic trials based on the natural history. Muscule and nerve. 1983;6:91-103. https://doi.org/10.1002/mus.880060204
15. Mazzone E., Vasco G., Sormani M. P. Functional changes in Duchenne muscular dystrophy: a 12-month longitudinal cohort study. Neurology. 2011;77:250-256. https://doi.org/10.1212/WNL.0b013e318225ab2e
16. Bonati U., Hafner P., Schädelin S. Quantitative muscle MRI: Apowerful surrogate outcome measure in Duchenne muscular dystrophy. Neuromuscular Disord. 2015;25(9):679-685. https://doi.org/10.1016/j.nmd.2015.05.006
17. Wokke B. H., Bos C., Reijnierse M. Comparison of Dixon and T1-weighted MR methods to assess the degree of fat infiltration in duchenne muscular dystrophy patients. J. Magn. Reson. Imaging. 2013;38(3):619-624. https://doi.org/10.1002/jmri.23998
18. Lamminen A. E. Magnetic resonance imaging of primary skeletal muscle diseases: Patterns of distribution and severity of involvement. Br. J. Radiol. 1990;63:946-950. https://doi.org/10.1259/0007-1285-63-756-946
Keywords: Duchenne muscular dystrophy, magnetic resonance imaging