logo
Medical news
of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137
rus
русский
eng
english

Site search



Correspondence address
310 Mira Street, Stavropol, Russia, 355017

Tel
+7 8652 352524; +7 8652 353229.

Fax
+7 8652 352524.

E-mail
medvestnik@stgmu.ru

Presepsin – a new biological marker for sepsis diagnosing and monitoring the effect of treatment

[Internal diseases]
Vladimir Kukes; Valeriy Marinin; Yury Olefir; Evgeniya Shih; Alexey Prokofiev; Dmitry Grapov; Dunya Verdieva; Nikolai Rumyantsev;

A retrospective analysis included 31 patients aged 23 to 78 years with the signs of SIRS from the departments of therapy, pulmonology and the intensive care unit (ICU) with the diagnosis of severe community-acquired or hospital-acquired pneumonia. The plasma level of presepsin protein was assessed using the Pathfast immunochemiluminescence analyzer (Japan). It was revealed that at hospitalization, the level of PSP was significantly higher in patients with SIRS than in healthy individuals. Patients with the diagnosis of sepsis (later confirmed by hemoculture) showed a higher concentration during hospitalization and at all subsequent time points of the study, which characterizes presepsin as a marker of sepsis in difficult clinical settings.

Download

References:
1. Slade E., Tamber P. S., Vincent J. L. The Surviving Sepsis Campaign: raising awereness to reduce mortality. Crit. Care. 2003;7(1):1-2.
2. Moore L. J., Moore F. A., Todd S. R., Jones S. L., Turner K. L., Bass B. L. Sepsis in general surgery: the 2005– 2007 national surgical quality improvement program perspective. Arch. Surg. 2010;145(7):695-700.
3. Kumar G., Kumar N., Taneja A., Kaleekal T., Tarima S. [et al.]. Nationwide trends of severe sepsis in the 21st century (2000–2007). Chest. 2011;140(5):1223-1231. https://doi.org/10.1378/chest.11-0352
4. Lagu T., Rothberg Michael B., Meng-Shiou Shieh, Pekow Penelope S., Steingrub Jay S., Lindenauer Peter K. Hospitalizations, costs, and outcomes of severe sepsis in the United States 2003 to 2007. Crit. Care Med. 2012;40(3):754-761.
5. Namas R., Zamora R., Namas R., An G., Doyle J. [et al.]. Sepsis: something old, something new, and a systems view. Crit. Care. 2012;27(3):314.E1-11. https://doi.org/10.1016/j.jcrc.2011.05.025
6. Aouifi A., Piriou V., Blanc P., Bouvier H., Bastien O. [et al.]. Effect of cardiopulmonary bypass on serum procalcitonin and C-reactive proteine concentrations. British Journal of Anaesthesia. 1999;83(4):602-607.
7. Dehne M. G., Sablotzki A., Hoffmann A. Alterations of acute phase reaction and cytokine production in patients following severe burn injury. Burns. 2002;28(6):535-542.
8. Sachse C., Machens H. G., Felmerer G. J. Procalcitonin as a marker for the early diagnosis of severe infection after thermal injury. Burn. Care Rehabil. 1999;20(5):354-360.
9. Benoist J. F., Mimoz O. Procalcitonin in severe trauma. Ann. Biol. Clin. (Paris). 1998;56(5):571-574.
10. Meisner M., Adina H., Schmidt J. Correlation of Procalcitonin and C-reactive proteine to inflammation, Complications, and outcome during the intensive care unit course of multiple-trauma patients. Crit. Care. 2006;10(1):R1. https://doi.org/10.1186/cc3910
11. Mimoz O., Benoist J. F., Edouard A. R., Assicot M., Bohuon C., Samii K. Procalcitonin and C-reactive protein during the early posttraumatic systemic inflammatory response syndrome. Intensive Care Med. 1998;24(2):185-188.
12. Sponholz C., Sakr Y., Reinhart K., Brunkhorst F. Diagnostic value and prognostic implications of serum procalcitonin after cardiac surgery: a systematic review of the literature. Crit. Care. 2006;10(5):R145. https://doi.org/10.1186/cc5067
13. Okamura Y., Thomae R. Presepsin: novyj biomarker dlja prognozirovanija i diagnostiki sepsisa. Laboratorija. Zhurnal dlja vrachej. – Lab. Journal for clinicians. 2014;(1):9-10. (In Russ.).
14. Shirakawa K., Naitou K., Hirose J., Nakamura M., Takeuchi T., Hosaka Y., Furusako S. The new sepsis marker, sSD14-ST, induction mechanism in the rabbit sepsis models. Critical. Care. 2010;14(2):19. https://doi.org/10.1186/cc9122
15. Yaegashi Y., Shirakawa K., Sato N., Suzuki Y., Kojika M. [et al.]. Evaluation of a newly identified soluble CD14 subtype as a marker for sepsis. Infect. Chemother. 2005;11(5):234- 238.
16. Romualdo L. G., Torrella P. E., González M. V., Sánchez R. J., Holgado A. H., Freire A. O., Acebes S. R., Otón M. D. Diagnostic accuracy of presepsin (soluble CD14 subtype) for prediction of bacteremia in patients with systemic inflammatory response syndrome in the emergency department. Clin. Biochem. 2014;47(7-8):505-508.
17. Shozushima T., Takahashi G., Matsumoto N., Kojika M., Okamura Y., Endo S. J. Usefulness of presepsin (sCD14- ST) measurements as a marker for the diagnosis and severity of sepsis that satisfied diagnostic criteria of systemic inflammatory response syndrome. Infect. Chemother. 2011;17(6):764-769.
18. Endo S., Suzuki Y., Takahashi G. Usefulness of presepsin in the diagnosis of sepsis in a multicenter prospective study. Infect. Chemother. 2012;18(6):891-897. https://doi.org/10.1007/s10156-012-0435-2
19. Assicot M., Gendrel D., Carsin H., Raymond J., Guilbaud J., Bohuon C. High serum procalcitonin concentrations in patients with sepsis and infection. Lancet. 1993;341(8844):515-518.
20. Vel’kov V. V. Kompleksnaja laboratornaja diagnostika sistemnyh infekcij i sepsisa: S-reaktivnyj belok, prokal’citonin, presepsin. Moscow: ZAO «Diakonlab», 2015. (In Russ.).

Keywords: systemic inflammatory response syndrome, sepsis, presepsin


Founders:
Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy