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Presepsin – a new biological marker for sepsis diagnosing and monitoring the effect of treatment

[Internal diseases]
Vladimir Kukes; Valeriy Marinin; Yury Olefir; Evgeniya Shih; Alexey Prokofiev; Dmitry Grapov; Dunya Verdieva; Nikolai Rumyantsev;

A retrospective analysis included 31 patients aged 23 to 78 years with the signs of SIRS from the departments of therapy, pulmonology and the intensive care unit (ICU) with the diagnosis of severe community-acquired or hospital-acquired pneumonia. The plasma level of presepsin protein was assessed using the Pathfast immunochemiluminescence analyzer (Japan). It was revealed that at hospitalization, the level of PSP was significantly higher in patients with SIRS than in healthy individuals. Patients with the diagnosis of sepsis (later confirmed by hemoculture) showed a higher concentration during hospitalization and at all subsequent time points of the study, which characterizes presepsin as a marker of sepsis in difficult clinical settings.


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Keywords: systemic inflammatory response syndrome, sepsis, presepsin

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy