Medical news
of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137

Site search

Correspondence address
310 Mira Street, Stavropol, Russia, 355017

+7 8652 352524; +7 8652 353229.

+7 8652 352524.


Linear skin atrophy: current information and modern approaches to the external therapy

Andrei Tishchenko; Vladimir Gorskii; Natalia Sergeeva;

The article presents literature data on the methods of correction of linear atrophy of the skin (striae). This pathology is widespread in both sexes. The decline in the quality of life in this disease occurs largely due to the presence of a cosmetic defect. To date, there is no universal therapeutic approach for the correction of stretch marks. In this article available literature data on the problem of linear atrophy of the skin has been summarized.


1. Stamatas G. N., Lopes-DaCunha A., Nkengne A., Bertin C. Biophysical properties of striae distensae evaluated in vivo using non-invasive assays. Skin Research and Technology. 2015;21(2):254-258. https://doi.org/10.1111/srt.12186
2. Lemperle G., Tenenhaus M., Knapp D., Lemperle Sm. I. The direction of optimal skin incisions derived from striae distensae. Plastic and reconstructive surgery. 2014;134(6):1424-1434. https://doi.org/10.1097/01.prs.0000438462.13840.21
3. Oakley A. M., Bhimji S. S. StatPearls [Internet]. Treasure Island (FL): StatPearls Pulishing; 2018-2017 May 28. PMID: 28613776.
4. Aldahan A. S., Shah V. V., Mlacker S., Samarkandy S., Alsaidan M. [et al.] Laser and Light Treatments for Striae Distensae: A Comprehensive Review of the Literature. Am. J. Clin. Dermatol. 2016;17(3):239-256. https://doi.org/10.1007/s40257-016-0182-8
5. Bleve M., Capra P., Pavanetto F., Perugini P. Ultrasound and 3D skin imaging: methods to evaluate efficacy of striae distensae treatment. Dermatol. Res. Prat. 2012; 2012:673706.
6. Brennan M., Young G., Devane D. Topical preparations for preventing stretch marks in pregnancy. Cochrane Database Syst. Rev. 2012;11:CD000066.
7. Al-Himdani Ud-Din S., Gilmore S., Bayat A. Striae distensae: a comprehensive review and evidence-based evaluation of prophylaxis and treatment. Br. J. Dermatol. 2014;170(3):527-547.
8. Ud-Din S., McAnelly S. L., Bowring A., Whiteside S., Morris J. [et al.] A double-blind controlled clinical trial assessing the effect of topical gels on striae distensae (stretch marks): a non-invasive imaging, morphological and immunohistochemical study. Arch. Dermatol. Res. 2013;305(7):603-617. https://doi.org/10.1007/s00403-013-1336-7
9. Korgavkar K., Wang F. Stretch marks during pregnancy: a review of topical prevention. Br. J. Dermatol. 2015;172:606-615.
10. Park K. K., Murase J. E. Connective Tissue Changes. in: G. Kroumpouzos (Ed.) Text Atlas of Obstetric Dermatology. Vol 1. Har/Psc ed. LWW, 2013.
11. Bahrami N., Soleimani M. A., Nia H. Sh., Masoodi R., Shaigan H. [et al.] Striae gravidarum in Iranian women: prevalence and associated factors. Life Sci. J. 2012; 9(4):3032-3037.
12. Yamaguchi K., Suganuma N., Ohashi K. Quality of life evaluation in Japanese pregnant women with striae gravidarum: A cross-sectional study. BMC Res. Notes. 2012;5:450.
13. Valente D. S., Zanella R. K., Doncatto L. F., Padoin A. V. Incidence and risk factors of striae distensae following breast augmentation surgery: a cohort study. PLoS ONE. 2014;9(5):e97493. https://doi.org/10.1371/journal.pone.0097493
14. Grimes H. A., Forster D. A., Newton M. S. Sources of information used by women during pregnancy to meet their information needs. Midwifery.2014;30(1):26–33. https://doi.org/10.1016/j.midw.2013.10.007
15. Wang F., Calderone K., Smith N. R., Do T. T., Helfrich Y. R. [et al.] Marked disruption and aberrant regulation of elastic fibres in early striae gravidarum. Br. J. Dermatol. 2015;173:1420-1430.
16. Gilmore S. J., Vaughan B. L., Madzvamuse A. Jr., Maini P. K. A mechanochemical model of striae distensae. Math. Biosci. 2012;240(2):141-147.
17. Tishchenko L. D., Khaddad S. M., Tishchenko A. L. Thiamin deficit in psoriatic patients abusing alcohol. Vestnik Dermatologii i Venerologii. 1995;5:40.
18. Sahbaz A., Aynioglu O., Isik H., Gulle K., Akpolat F. M. [et al.] Cholecalciferol (vitamin D3) prevents postoperative adhesion formation by inactivating the nuclear factor kappa B pathway: a randomized experimental study. Journal of Surgical Research. 2015;198(1):252-259. https://doi.org/10.1016/j.jss.2015.05.010
19. Upala S., Sanguankeo A., Permpalung N. Significant association between vitamin D deficiency and sepsis: a systematic review and meta-analysis. BMC Anesthesiology. 2015;15:84. https://doi.org/10.1186/s12871-015-0063-3
20. Samochocki Z., Bogaczewicz J., Jeziorkowska R., Sysa-Jędrzejowska A., Glińska O. [et al.] Vitamin D effects in atopic dermatitis. Journal of the American Academy of Dermatology. 2013;69(2):238-244. https://doi.org/10.1016/j.jaad.2013.03.014
21. Wacker M., Holiack M. F. Vitamin D-effects on skeletal and extraskeletal health and the need for supplementation. Nutrients. 2013;5(1):111-148. https://doi.org/10.3390/nu5010111
22. Reddy K. K., Gilchrest B. A. The role of vitamin D in melanoma prevention: evidence and hyperbole. Journal of the American Academy of Dermatology. 2014;71(5):1004-1005. https://doi.org/10.1016/j.jaad.2014.08.013
23. Curiel-Lewandrowski C., Tang J. Y., Einspahr J. G. [et al.] Pilot study on the bioactivity of vitamin D in the skin after oral supplementation. Cancer Prevention Research (Phila). 2015;8(6):563-569.
24. Soleymani T., Hung T., Soung J. The role of vitamin D in psoriasis: a review. International Journal of Dermatology. 2015;54(4):383-392. doi: 10.1111/ijd.12790
25. Chang E. M., Kim Y. S., Won H. J., Yoon T. K., Lee W. S. Association between sex steroids, ovarian reserve, and vitamin D levels in healthy nonobese women. The Journal of Clinical Endocrinology & Metabolism. 2014; 99(7):2526-2532. https://doi.org/10.1210/jc.2013-3873
26. Narvaez C. J., Matthews D., LaPorta E., Simmons K. M., Beaudin S. [et al.] The impact of vitamin D in breast cancer: genomics, pathways, metabolism. Frontiers in Physiology. 2014;5:213. https://doi.org/10.3389/fphys.2014.00213
27. Guimarães P. A. M., Haddad A., Sabino Neto M., Lage F. C., Ferreira L. M. [et al.] Striae distensae after breast augmentation: treatment using the nonablative fractionated 1550-nm erbium glass laser. Plastic and Reconstructive Surgery. 2013;131(3):636-642. https://doi.org/10.1097/prs.0b013e31827c7010
28. Narin R., Nazik H., Narin M. A., Nazik E., Özdemir F. [et al.] Can different geographic conditions affect the formation of striae gravidarum? A multicentric study. J. Obstet. Gynaecol. Res. 2015;41(9):1377-1383. https://doi.org/10.1111/jog.12741
29. Kasielska-Trojan A., Sobczak M., Antoszweski B. Risk factors of striae gravidarum. Int. J. Cosmet. Sci. 2015;37:236-240.
30. Picard D., Sellier S., Houivet E., Marpeau L., Fournet P. [et al.] Incidence and risk factors for striae gravidarum. J. Am. Acad. Dermatol. 2015;73:699-700.
31. Ersoy E., Ersoy A. O., Celik Y. E., Tokmak A., Ozler S. [et al.] Is it possible to prevent striae gravidarum? J. Chin. Med. Assoc. 2016;79:272-275.
32. Nassar A., Ghomey S., El Gohary Y., El-Desoky F. Treatment of striae distensae with needling therapy versus microdermabrasion with sonophoresis. J. Cosmet. Laser Ther. 2016;18:330-334.
33. Ud-Din S., McGeorge D., Bayat A. Topical management of striae distensae (stretch marks): prevention and therapy of striae rubrae and albae. J. Eur. Acad. Dermatol. Venereol. 2016;30(2):211-222.
34. Mazzarello V., Farace F., Ena P. [et al.] A superficial texture analysis of 70 % glycolic acid topical therapy and striae distensae. Plast. Reconstr. Surg. 2012;129(3):589-590.
35. Al-Dhalimi M. A., Abo Nasyria. A. A. A comparative study of the effectiveness of intense pulsed light wavelengths (650 nm vs 590 nm) in the treatment of striae distensae. J. Cosmet. Laser Ther. 2013;15:120-125.
36. Aldahan A. S., Shah V. V., Mlacker S., Samarkandy S., Alsaidan M. [et al.] Laser and light treatments for striae distensae: A comprehensive review of the literature. Am. J. Clin. Dermatol. 2016;17:239-256.
37. Malekzad F., Shakoei S., Ayatollahi A., Hejazi S. The safety and efficacy of the 1540nm non-ablative fractional XD probe of star lux 500 device in the treatment of striae Alba: Before-after study. J. Lasers Med. Sci. 2014;5:194-198.
38. Tretti Clementoni M., Lavagno R. A. Novel 1565 nm nonablative fractional device for stretch marks: A preliminary report. J. Cosmet. Laser Ther. 2015;17:148-155.
39. Farahnik B., Park K., Kroumpouzos G., Murase J. Striae gravidarum: Risk factors, prevention, and management Int. J. Womens Dermatol. 2017;3(2):77-85. https://doi.org/10.1016/j.ijwd.2016.11.001
40. Nassar A., Ghomey S., El Gohary Y., El-Desoky F. Treatment of striae distensae with needling therapy versus microdermabrasion with sonophoresis. J. Cosmet. Laser Ther. 2016;18:330-334.
41. Jadoon S., Karim S., Bin Asad M. H. [et al.] Anti-aging potential of phytoextract loaded-pharmaceutical creams for human skin cell longetivity. Oxid Med. Cell. Longev. 2015;2015:709628.
42. Hernández G. J. Á., González M. D., Castillo P. M., Figueras F. T. Use of a specific anti-stretch mark cream for preventing or reducing the severity of striae gravidarum. Randomized, double-blind, controlled trial. Int. J. Cosmet. Sci. 2013;35:233-237.
43. Alaiti S., webpage on the Internet Striae Distensae Treatment & Management. Accessed July 26, 2016. [cited May 20, 2015]. Available at: http://emedicine.medscape.com/article/1074868-treatment
44. Crisan D., Crisan M., Moldovan M., Lupsor M., Badea R. Ultrasonographic assessment of the cutaneous changes induced by topical flavonoid therapy. Clin. Cosmet. Investig. Dermatol. 2012;5:7-13.
45. Yamaguchi K., Suganuma N., Ohashi K. Prevention of striae gravidarum and quality of life among pregnant Japanese women. Midwifery. 2014;30(6):595-599.
46. Soltanipour F., Delaram M., Taavoni S., Haghani H. The effect of olive oil on prevention of striae gravidarum: A randomized controlled clinical trial. Complement Ther. Med. 2012;20:263-266.
47. Soltanipour F., Delaram M., Taavoni S., and Haghani H. The effect of olive oil and the Saj cream in prevention of striae gravidarum: A randomized controlled clinical trial. Complement Ther. Med. 2014;22:220-225.
48. Timur Taşhan S., Kafkasli A. The effect of bitter almond oil and massaging on striae gravidarum in primiparous women. J. Clin. Nurs. 2012;21:1570-1576.
49. Rahimi H. R., Arastoo M., Ostad S. N. A comprehensive review of Punica granatum (Pomegranate) properties in toxicological, pharmacological, cellular and molecular biology researches. Iran J. Pharm. Res. 2012;11(2):385-400.
50. Lauche R., Kumar S., Hallmann J. [et al.] Efficacy and safety of ayurvedic herbs in diarrhoea-predominant irritable bowel syndrome: a randomised controlled crossover trial. Complement Ther. Med. 2016;26:171-177.
51. Namjoyan F., Kiashi F., Moosavi Z. B., Saffari F., Makhmalzadeh B. S. Efficacy of Dragon’s blood cream on wound healing: a randomized, double-blind, placebocontrolled clinical trial. J. Tradit. Complement Med. 2015;6(1):37-40.
52. Djuris J., Vasiljevic D., Jokic S., Ibric S. Application of D-optimal experimental design method to optimize the formulation of O/W cosmetic emulsions. Int. J. Cosmet. Sci. 2014;36(1):79-87.
53. Lukic M., Jaksic I., Krstonosic V., Cekic N., Savic S. A combined approach in characterization of an effective W/O hand cream: the influence of emollient on textural, sensorial and in vivo skin performance. Int. J. Cosmet. Sci.2012;34(2):140-149.
54. Kozel B. A., Bayliss S. J., Berk D. R. [et al.] Skin findings in Williams syndrome. Am. J. Med. Genet A. 2014;164A (9):2217-2225.
55. Hadi H., Awadh A. I., Hanif N. M., Md Sidik N. F., Mohd Rani M. R. [et al.] The investigation of the skin biophysical measurements focusing on daily activities, skin care habits, and gender differences. Skin. Res. Technol. 2016;22(2):247-254.
56. Rawlings A. V., Bielfeldt S., Lombar K. J. A review of the effects of moisturizers on the appearance of scars and striae. Int. J. Cosmet. Sci. 2012;34(6):519-524.
57. Chularojanamontri L., Tuchinda P., Kulthanan K., Pongparit K. Moisturizers for acne: what are their constituents? J. Clin. Aesthet. Dermatol. 2014;7(5):36-44.
58. Vil’son S., Tishchenko A. L., Gorskii V. S. Assessment of the ability of lymphocytes to activate background local injections of acidic peptidoglycan in patients with acne. Klinicheskaja dermatologija i venerologija. 2015;(3):14: 37-39.

Keywords: stretch marks, ethiopathogenesis, topical therapy

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy