310 Mira Street, Stavropol, Russia, 355017
+7 8652 352524; +7 8652 353229.
+7 8652 352524.
The journal is included into The list of leading scientific periodicals.
This study was undertaken to evaluate the structure of bone and soft tissues of the rabbit oral cavity during and after long-term corticosteroid therapy. Osteoporotic changes in bone tissue were noted from the 12th day after the beginning of the experiment and progressed to the 30th day of the use of glucocorticoids. Dentin and tooth enamel were resistant to the action of the hormone. After the abolition of the 30-day course of hydrocortisone, normal structures were restored by day 16, and by the end of the experiment (day 30), there were no pathological changes in the bone or soft tissues of the teeth. Subsequently, the predentin zone was restored. These changes in bone tissue after the cessation of limiting therapy are reversible, which indicates the need for a more critical attitude towards those patients taking corticosteroids as an antiinflammatory therapy.
1. Golovach I. Y. Glucocorticoid-induced osteoporosis: historical aspects and modern approaches to prevention and treatment. Farmateka. – Pharmatec. 2015;(4):50-55.
2. Compston J., Cooper A., Cooper C. UK clinical guideline for the prevention and treatment of osteoporosis. Arch. Osteoporos. 2017;12(1):43.
3. Subramaniam S., Ima-Nirwana S., Chin K.-Y. Performance of osteoporosis self-assessment tool (OST) in predicting osteoporosis – a review. Int. J. Environ. Res. Pub. Health. 2018;15(7):1445. https://doi.org/10.3390/ijerph15071445
4. Sirak S. V., Shchetinin E. V., Sirak A. G. Pathomorphological changes of dental pulp in experimental osteoporosis. Medical News of North Caucasus. 2016;11(2):210-213. https://doi.org/10.14300/mnnc.2016.11039
5. Basov A. A., Baryshev M. G., Bykov I. M., Pavljuchenko I. I., Dzhimak S. S. [et. al.] The effect of water with a modified isotope composition on the intensity of free radical processes in an experiment on laboratory animals. Allergologija i immunologija. – Allergology Immunology. 2012;13(4):314-320.
6. Kulakov A. A., Goldshtein D. B., Gigoryan A. S., Rzhaninova А. А., Alekseeva I. S. [et. al.] Clinical study of the efficiency of combined cell transplant on the basis of multipotentmesenchymal stromal cells of adipose tissue in patients with severe deficiency of bone in the upper and lower jaw. Kletochnie technologii v biologii i medicine. – Cell technologies in biology and medicine. 2008;(4):206- 210.
7. Shchetinin E. V., Sirak S. V., Koshel I. V., Kobylkina T. L., Dygov E. A. Morphological characteristics of periodontaltissues in experimental osteoporosis. Medical News of North Caucasus. 2016;11(3):373-376. https://doi.org/10.14300/mnnc.2016.11081
8. Sirak S. V., Shchetinin E. V., Bobryshev D. V., Fritsch T., Giesenhagen B. [et. al.] Osteoporotic sheep mandibular model for comparative alveolar bone healing research. Medical News of North Caucasus. 2017;12(3):284-289. https://doi.org/10.14300/mnnc.2017.12091
9. Murshid S. A. The role of osteocytes during experimental orthodontic tooth movement: A review. Arch. Oral Biol. 2017;73:25-33. https://doi.org/10.1016/j.archoralbio.2016.09.001
10. Myles T. D. Steroids – Plenty of benefits, but not without risk. Obstet. Gynecol. 2011;117(2-2):429-430. https://doi.org/10.1097/AOG.0b013e31820711f0
11. Hochberg Z. Mechanisms of steroid impairment of growth. Hormone Res. 2002;58(Suppl. 1):33-38. https://doi.org/10.1159/000064764
12. Arends S., Spoorenberg A., Bruyn G. A. W., Houtman P. M., Leijsma M. K. [et al.] The relation between bone mineral density, bone turnover markers, and vitamin D status in ankylosing spondylitis patients withactive disease: a cross-sectional analysis. Osteoporos Int. 2011;22:1431-1439. https://doi.org/10.1007/s00198-010-1338-7
13. Siu S., Haraoui B., Bissonnette R., Bessette L., Roubille C. [et al.] Meta-Analysis of Tumor Necrosis Factor Inhibitors and Glucocorticoids on Bone Density in Rheumatoid Arthritis and Ankylosing Spondylitis Trials. Arthritis Care Res. 2015;67(6):754-764. https://doi.org/10.1002/acr.22519
14. Ramíreza J., Nieto-Gonzálezb J. C., Rodríguezc R. C., Castañedad S., Carmona L. Prevalence and risk factors for osteoporosis and fractures in axial spondyloarthritis: A systematic review and meta-analysis. Sem. Arthritis Rheumatism. 2018;48(1):44-52. https://doi.org/10.1016/j.semarthrit.2017.12.001
Keywords: corticosteroid therapy, osteoporosis, bone tissue