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Drug induced patomorphosis in parodont and environmental bone tissue in experimental use of corticosteroids

[Experimental medicine]
Vasilii Tsygan; Konstantin Shulenin; Sergey Koskin; Aleksandr Kovalevsky; Irina Borodulina; Sergey Risovanniy; Sergey Sirak; Evgeny Shchetinin;

This study was undertaken to evaluate the structure of bone and soft tissues of the rabbit oral cavity during and after long-term corticosteroid therapy. Osteoporotic changes in bone tissue were noted from the 12th day after the beginning of the experiment and progressed to the 30th day of the use of glucocorticoids. Dentin and tooth enamel were resistant to the action of the hormone. After the abolition of the 30-day course of hydrocortisone, normal structures were restored by day 16, and by the end of the experiment (day 30), there were no pathological changes in the bone or soft tissues of the teeth. Subsequently, the predentin zone was restored. These changes in bone tissue after the cessation of limiting therapy are reversible, which indicates the need for a more critical attitude towards those patients taking corticosteroids as an antiinflammatory therapy.

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Keywords: corticosteroid therapy, osteoporosis, bone tissue


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