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Medical news
of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137
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Effect of niosomal antimicrobial peptide hBD-1 on the healing rate of infected wounds in rats

[Experimental medicine]
Albert Bolatchiev; Vladimir Baturin; Igor Bazikov; Alexander Maltsev;

In this study we investigated the effect of an antimicrobial peptide hBD-1 capsulated in organosilicon nanocontainers (niosomes) on the healing rate of experimental wounds infected with the clinical strain of Staphylococcus aureus. It was shown that the niosomal gel containing recombinant hBD-1 (1 μg/ml) increases the linear healing rate of infected wounds in rats compared to the control group.

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References:
1. Prestinaci F., Pezzotti P., Pantosti A. Antimicrobial resistance: a global multifaceted phenomenon. Pathog. Glob. Health. 2015;109(7):309-318. https://doi.org/10.1179/2047773215Y.0000000030
2. Steckbeck J. D., Deslouches B., Montelaro R. C. Antimicrobial peptides: new drugs for bad bugs? Expert Opin. Biol. Ther. 2014;14(1):11-14. https://doi.org/10.1517/14712598.2013.844227
3. Watermann A. Mesoporous Silica Nanoparticles as Drug Delivery Vehicles in Cancer. Nanomaterials. 2017;7(7):189. https://doi.org/10.3390/nano7070189
4. The patent of the Russian Federation for the invention № 2655522 / 28.05.2018 Bulletin № 16. Bolatchiev A. D., Baturin V. A., Bazikov I. A. Antimicrobial gel for the treatment of infected wounds, burns and trophic ulcers. Available at: http://www1.fips.ru/fips_servl/fips_servle?DB=RUPAT&DocNumber=2655522&TypeFile=html. Link is active on 03.08.2018.

Keywords: antimicrobial peptide, defensin, niosome, antibiotic resistance, hBD-1


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Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy