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of the North Caucasus
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ISSN 2073-8137

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Effect of niosomal antimicrobial peptide hBD-1 on the healing rate of infected wounds in rats

[Experimental medicine]
Albert Bolatchiev; Vladimir Baturin; Igor Bazikov; Alexander Maltsev;

In this study we investigated the effect of an antimicrobial peptide hBD-1 capsulated in organosilicon nanocontainers (niosomes) on the healing rate of experimental wounds infected with the clinical strain of Staphylococcus aureus. It was shown that the niosomal gel containing recombinant hBD-1 (1 μg/ml) increases the linear healing rate of infected wounds in rats compared to the control group.


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Keywords: antimicrobial peptide, defensin, niosome, antibiotic resistance, hBD-1

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy