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https://doi.org/10.14300/mnnc.2018.13061

Effect of chronic administration of fluoxetine, melatonin and their combination on the timecourse of the circadian rhythm of motor activity in rats

[Experimental medicine]
Olga Kaminskaya; Alexey Popov;

Single and complex effects of melatonin (0.5 mg/kg) and fluoxetine (5 mg/kg) on the dynamics of the circadian rhythm of locomotor activity of rats were studied. Chronic injecting stress caused disruption of circadian rhythm of mobility with in its amplitude, increase of acrophase instability and change of spectral characteristics. Melatonin in combination with fluoxetine better then single antidepressant administration prevented rhythm disruption. It was assumed that application of the above combination of substances in clinical practice is promising.

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Keywords: melatonin, fluoxetine, combined use