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Stress -induced disorders of the metabolic activity of periodontal tissue in experimental animals and possibility of its correction

[Experimental medicine]
Sergey Sirak; Gregory Petrosyan; Evgeny Shchetinin; Roman Romanenko; Anna Tarabrina; Aleksandr Mirolyubov;

The article is devoted to the pathomorphological assessment of the metabolic activity of periodontal tissues in the experimental model of chronic stress performed by stress-inducing device for a non-physiological occlusion of the jaws in rats. The objects were 78 mature white laboratory rats. The data obtained has demonstrated that ethylmethylhydroxypyridine succinate prevents the development of pathological changes in the walls of blood vessels of the periodontium under conditions of the chronic stress. It also helps to improve the local blood circulation and has a stimulating effect on the oxidative phosphorylation and, so, can be recommended for the directed metabolic correction of gingival oxygen deficiency caused by prolonged chronic stress.

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Keywords: stress, periodontal disease, experiment, metabolism, hypoxia


Founders:
Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy